A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Programmable immune activating electrospun fibers for skin regeneration
Tekijät: Chen Lu, Zhang Liucheng, Zhang Hongbo, Sun Xiaoming, Liu Dan, Zhang Jianming, Zhang Yuguang, Cheng Liying, Santos Hélder A, Cui Wenguo
Kustantaja: KEAI PUBLISHING LTD
Julkaisuvuosi: 2021
Journal: Bioactive Materials
Tietokannassa oleva lehden nimi: BIOACTIVE MATERIALS
Lehden akronyymi: BIOACT MATER
Vuosikerta: 6
Numero: 10
Aloitussivu: 3218
Lopetussivu: 3230
Sivujen määrä: 13
eISSN: 2452-199X
DOI: https://doi.org/10.1016/j.bioactmat.2021.02.022
Tiivistelmä
Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing. How to programmatically activate sequential immune responses is the key for scarless skin regeneration. In this study, an "Inner-Outer" IL-10-loaded electrospun fiber with cascade release behavior was constructed. During the inflammatory phase, the electrospun fiber released a lower concentration of IL-10 within the wound, inhibiting excessive recruitment of inflammatory cells and polarizing macrophages into anti-inflammatory phenotype "M2c" to suppress excessive inflammation response. During the proliferative phase, a higher concentration of IL10 released by the fiber and the anti-fibrotic cytokines secreted by polarized "M2c" directly acted on dermal fibroblasts to simultaneously inhibit extracellular matrix overdeposition and promote fibroblast migration. The "Inner-Outer" IL-10-loaded electrospun fiber programmatically activated the sequential immune responses during wound healing and led to scarless skin regeneration, which is a promising immunomodulatory biomaterial with great potential for promoting complete tissue regeneration.
Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing. How to programmatically activate sequential immune responses is the key for scarless skin regeneration. In this study, an "Inner-Outer" IL-10-loaded electrospun fiber with cascade release behavior was constructed. During the inflammatory phase, the electrospun fiber released a lower concentration of IL-10 within the wound, inhibiting excessive recruitment of inflammatory cells and polarizing macrophages into anti-inflammatory phenotype "M2c" to suppress excessive inflammation response. During the proliferative phase, a higher concentration of IL10 released by the fiber and the anti-fibrotic cytokines secreted by polarized "M2c" directly acted on dermal fibroblasts to simultaneously inhibit extracellular matrix overdeposition and promote fibroblast migration. The "Inner-Outer" IL-10-loaded electrospun fiber programmatically activated the sequential immune responses during wound healing and led to scarless skin regeneration, which is a promising immunomodulatory biomaterial with great potential for promoting complete tissue regeneration.
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