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Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder




Julkaisun tekijät: Mazumder Atiqui Haq, Barnett Jennifer, Lindberg Nina, Torniainen-Holm Minna, Lähteenvuo Markku, Lahdensuo Kaisa, Kerkelä Martta, Hietala Jarmo, Isometsä Erkki Tapio, Kampman Olli, Kieseppä Tuula, Jukuri Tuomas, Häkkinen Katja, Cederlöf Erik, Haaki Willehard, Kajanne Risto, Wegelius Asko, Männynsalo Teemu, Niemi-Pynttäri Jussi, Suokas Kimmo, Lönnqvist Jouko, Niemela Solja, Tiihonen Jari, Paunio Tiina, Palotie Aarno, Suvisaari Jaana, Veijola Juha

Kustantaja: MDPI

Julkaisuvuosi: 2021

Journal: Brain Sciences

Tietokannassa oleva lehden nimi: BRAIN SCIENCES

Lehden akronyymi: BRAIN SCI

Volyymi: 11

Julkaisunumero: 6

Sivujen määrä: 16

DOI: http://dx.doi.org/10.3390/brainsci11060688

Verkko-osoite: https://doi.org/10.3390/brainsci11060688

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66433671


Tiivistelmä
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.

Ladattava julkaisu

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Last updated on 2022-07-04 at 18:34