A1 Refereed original research article in a scientific journal
Kinetic analysis and optimisation of 18F-rhPSMA-7.3 PET imaging of prostate cancer
Authors: Malaspina Simona, Oikonen Vesa, Kuisma Anna, Ettala Otto, Mattila Kalle, Boström Peter J., Minn Heikki, Kalliokoski Kari, Postema Ernst J., Miller Matthew P., Scheinin Mika
Publisher: SPRINGER
Publication year: 2021
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Journal acronym: EUR J NUCL MED MOL I
Volume: 48
First page : 3723
Last page: 3731
Number of pages: 9
ISSN: 1619-7070
eISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05346-8
Web address : https://link.springer.com/article/10.1007/s00259-021-05346-8
Self-archived copy’s web address: https://research.utu.fi/converis/portal/Publication/58756678
Purpose
This phase 1 open-label study evaluated the uptake kinetics of a novel theranostic PET radiopharmaceutical, F-18-rhPSMA-7.3, to optimise its use for imaging of prostate cancer.
Methods
Nine men, three with high-risk localised prostate cancer, three with treatment-naive hormone-sensitive metastatic disease and three with castration-resistant metastatic disease, underwent dynamic 45-min PET scanning of a target area immediately post-injection of 300 MBq F-18-rhPSMA-7.3, followed by two whole-body PET/CT scans acquired from 60 and 90 min post-injection. Volumes of interest (VoIs) corresponding to prostate cancer lesions and reference tissues were recorded. Standardised uptake values (SUV) and lesion-to-reference ratios were calculated for 3 time frames: 35-45, 60-88 and 90-118 min. Net influx rates (K-i) were calculated using Patlak plots.
Results
Altogether, 44 lesions from the target area were identified. Optimal visual lesion detection started 60 min post-injection. The F-18-rhPSMA-7.3 signal from prostate cancer lesions increased over time, while reference tissue signals remained stable or decreased. The mean (SD) SUV (g/mL) at the 3 time frames were 8.4 (5.6), 10.1 (7) and 10.6 (7.5), respectively, for prostate lesions, 11.2 (4.3), 13 (4.8) and 14 (5.2) for lymph node metastases, and 4.6 (2.6), 5.7 (3.1) and 6.4 (3.5) for bone metastases. The mean (SD) lesion-to-reference ratio increases from the earliest to the 2 later time frames were 40% (10) and 59% (9), respectively, for the prostate, 65% (27) and 125% (47) for metastatic lymph nodes and 25% (19) and 32% (30) for bone lesions. Patlak plots from lesion VoIs signified almost irreversible uptake kinetics. K-i, SUV and lesion-to-reference ratio estimates showed good agreement.
Conclusion
F-18-rhPSMA-7.3 uptake in prostate cancer lesions was high. Lesion-to-background ratios increased over time, with optimal visual detection starting from 60 min post-injection. Thus, F-18-rhPSMA-7.3 emerges as a very promising PET radiopharmaceutical for diagnostic imaging of prostate cancer.
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