A1 Journal article – refereed

Hammersmith Infant Neurological Examination and long-term cognitive outcome in children born very preterm




List of Authors: Uusitalo Karoliina, Haataja Leena, Nyman Anna, Lehtonen Tuomo, Setänen Sirkku

Publisher: WILEY

Publication year: 2021

Journal: Developmental Medicine and Child Neurology

Journal name in source: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Journal acronym: DEV MED CHILD NEUROL

Number of pages: 7

ISSN: 0012-1622

DOI: http://dx.doi.org/10.1111/dmcn.14873

URL: https://doi.org/10.1111/dmcn.14873


Abstract
Aim To study the association between the Hammersmith Infant Neurological Examination (HINE) at age 2 years and neurocognition at age 11 years in children born very preterm. We hypothesized that the HINE at 2 years would be associated with neurocognition, that is, neurological, motor, and cognitive outcomes at 11 years.Method A total of 174 children (mean gestational age 29.0wks, SD 2.7; minimum 23.0, maximum 35.9; 95 [55%] males, 79 [45%] females) born very preterm (birthweight <= 1500g/gestational age <32wks), were included in a prospective cohort recruited from 2001 to 2006 in Turku, Finland. The HINE was performed at 2 years' corrected age. Neurocognition at 11 years was assessed with the Touwen Infant Neurological Examination (TINE) , Movement Assessment Battery for Children, Second Edition (MABC-2), and full-scale IQ (Wechsler Intelligence Scale for Children, Fourth Edition).Results The HINE global score was associated with the results of the TINE (odds ratio [OR]=0.9, 95% confidence interval [CI] 0.8-0.9, p=0.001), MABC-2 (beta=1.4, 95% CI 0.7-2.2, p<0.001), and full-scale IQ (beta=1.2, 95% CI 0.8-1.7, p<0.001), even when adjusted. When children with cerebral palsy (CP) were excluded, the HINE was still associated with full-scale IQ (unadjusted beta=1.2, 95% CI 0.3-2.1, p=0.01).Interpretation A higher HINE global score at 2 years was associated with better general intelligence at 11 years even in children without CP. The HINE may be a useful tool to detect children at risk for later cognitive impairment.

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Last updated on 2021-24-06 at 08:27