A1 Journal article – refereed

Hammersmith Infant Neurological Examination and long-term cognitive outcome in children born very preterm

List of Authors: Uusitalo Karoliina, Haataja Leena, Nyman Anna, Lehtonen Tuomo, Setänen Sirkku

Publisher: WILEY

Publication year: 2021

Journal: Developmental Medicine and Child Neurology


Journal acronym: DEV MED CHILD NEUROL

Number of pages: 7

ISSN: 0012-1622

DOI: http://dx.doi.org/10.1111/dmcn.14873

URL: https://doi.org/10.1111/dmcn.14873

Aim To study the association between the Hammersmith Infant Neurological Examination (HINE) at age 2 years and neurocognition at age 11 years in children born very preterm. We hypothesized that the HINE at 2 years would be associated with neurocognition, that is, neurological, motor, and cognitive outcomes at 11 years.Method A total of 174 children (mean gestational age 29.0wks, SD 2.7; minimum 23.0, maximum 35.9; 95 [55%] males, 79 [45%] females) born very preterm (birthweight <= 1500g/gestational age <32wks), were included in a prospective cohort recruited from 2001 to 2006 in Turku, Finland. The HINE was performed at 2 years' corrected age. Neurocognition at 11 years was assessed with the Touwen Infant Neurological Examination (TINE) , Movement Assessment Battery for Children, Second Edition (MABC-2), and full-scale IQ (Wechsler Intelligence Scale for Children, Fourth Edition).Results The HINE global score was associated with the results of the TINE (odds ratio [OR]=0.9, 95% confidence interval [CI] 0.8-0.9, p=0.001), MABC-2 (beta=1.4, 95% CI 0.7-2.2, p<0.001), and full-scale IQ (beta=1.2, 95% CI 0.8-1.7, p<0.001), even when adjusted. When children with cerebral palsy (CP) were excluded, the HINE was still associated with full-scale IQ (unadjusted beta=1.2, 95% CI 0.3-2.1, p=0.01).Interpretation A higher HINE global score at 2 years was associated with better general intelligence at 11 years even in children without CP. The HINE may be a useful tool to detect children at risk for later cognitive impairment.

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Last updated on 2021-24-06 at 08:27