Refereed journal article or data article (A1)

Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes




List of Authors: Csengeri Dora, Sprünker Ngoc-Anh, Di Castelnuovo Augusto, Niiranen Teemu, Vishram-Nielsen Julie Kk, Costanzo Simona, Söderberg Stefan, Jensen Steen M, Vartiainen Erkki, Donati Maria Benedetta, Magnussen Christina, Camen Stephan, Gianfagna Francesco, Løchen Maja-Lisa, Kee Frank, Kontto Jukka, Mathiesen Ellisiv B, Koenig Wolfgang, Blankenberg Stefan, de Gaetano Giovanni, Jørgensen Torben, Kuulasmaa Kari, Zeller Tanja, Salomaa Veikko, Iacoviello Licia, Schnabel Renate B

Publisher: OXFORD UNIV PRESS

Publication year: 2021

Journal: European Heart Journal

Journal name in source: EUROPEAN HEART JOURNAL

Journal acronym: EUR HEART J

Volume number: 42

Issue number: 12

Number of pages: 8

ISSN: 0195-668X

DOI: http://dx.doi.org/10.1093/eurheartj/ehaa953

URL: https://doi.org/10.1093/eurheartj/ehaa953

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/54798641


Abstract

Aims

There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.

Methods and results

In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.

Conclusions

In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.


Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Last updated on 2022-06-10 at 13:15