A1 Refereed original research article in a scientific journal

Are Breast Cancer Nomograms Still Valid to Predict the Need for Axillary Dissection?




AuthorsMadekivi Vilma, Karlsson Antti, Boström Pia, Salminen Eeva

PublisherKARGER

Publication year2021

JournalOncology

Journal name in sourceONCOLOGY

Journal acronymONCOLOGY-BASEL

Volume99

Issue6

First page 397

Last page401

Number of pages5

ISSN0030-2414

eISSN1423-0232

DOIhttps://doi.org/10.1159/000514616


Abstract
Background: Nomograms can help in estimating the nodal status among clinically node-negative patients. Yet their validity in external cohorts over time is unknown. If the nodal stage can be estimated preoperatively, the need for axillary dissection can be decided. 
Objectives: The aim of this study was to validate three existing nomograms predicting 4 or more axillary lymph node metastases. 
Method: The risk for >= 4 lymph node metastases was calculated for n = 529 eligible breast cancer patients using the nomograms of Chagpar et al. [Ann Surg Oncol. 2007;14:670-7], Katz et al. [J Clin Oncol. 2008;26(13):2093-8], and Meretoja et al. [Breast Cancer Res Treat. 2013;138(3):817-27]. Discrimination and calibration were calculated for each nomogram to determine their validity. 
Results: In this cohort, the AUC values for the Chagpar, Katz, and Meretoja models were 0.79 (95% CI 0.74-0.83), 0.87 (95% CI 0.83-0.91), and 0.82 (95% CI 0.76-0.86), respectively, showing good discrimination between patients with and without high nodal burdens. 
Conclusion: This study presents support for the use of older breast cancer nomograms and confirms their current validity in an external population.



Last updated on 2024-26-11 at 16:18