A1 Refereed original research article in a scientific journal
The influence of a matrix metalloproteinase on the remineralization of artificially demineralized dentin
Authors: Nordbø H, Leirskar J, Ngo H, Mount GJ, Wahlgren J
Publication year: 2003
Journal: Oral Health and Preventive Dentistry
Journal name in source: Oral health & preventive dentistry
Journal acronym: Oral Health Prev Dent
Volume: 1
Issue: 4
First page : 267
Last page: 72
ISSN: 1602-1622
Abstract
This investigation aimed at determining whether a collagenolytic matrix metalloproteinase (MMP-8) present in the oral fluids might attack demineralized dentin and thereby affect the potential for remineralization.\nDentin specimens from freshly extracted third molars were demineralized for 14 days in vitro and then remineralized for 7 days in the presence or absence of activated MMP-8. Following treatment the mineral level of the specimens was assessed from the outer dentinal surface using Electron Probe Micro Analysis (EPMA).\nThe findings suggested that the addition of activated MMP-8 to the remineralizing solution led to reduced remineralization in the surface of the dentin. There appeared to be no effect on the remineralization from any dentin bound MMP activity.\nIt appears that MMP-8 may negatively influence the remineralization of demineralized dentin.\nPURPOSE\nMATERIALS AND METHODS\nRESULTS\nCONCLUSION
This investigation aimed at determining whether a collagenolytic matrix metalloproteinase (MMP-8) present in the oral fluids might attack demineralized dentin and thereby affect the potential for remineralization.\nDentin specimens from freshly extracted third molars were demineralized for 14 days in vitro and then remineralized for 7 days in the presence or absence of activated MMP-8. Following treatment the mineral level of the specimens was assessed from the outer dentinal surface using Electron Probe Micro Analysis (EPMA).\nThe findings suggested that the addition of activated MMP-8 to the remineralizing solution led to reduced remineralization in the surface of the dentin. There appeared to be no effect on the remineralization from any dentin bound MMP activity.\nIt appears that MMP-8 may negatively influence the remineralization of demineralized dentin.\nPURPOSE\nMATERIALS AND METHODS\nRESULTS\nCONCLUSION
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