A1 Refereed original research article in a scientific journal
Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma
Authors: Renkonen S, Cardell LO, Mattila P, Lundberg M, Haglund C, Hagström J, Mäkitie AA
Publication year: 2015
Journal: APMIS
Journal name in source: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Journal acronym: APMIS
Volume: 123
Issue: 5
First page : 439
Last page: 44
Number of pages: 6
ISSN: 0903-4641
eISSN: 1600-0463
DOI: https://doi.org/10.1111/apm.12366
Abstract
Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign tumor affecting adolescent males. The etiology of JNA as well as the causes determining the variable growth patterns of individual tumors remains unknown. Toll-like receptors (TLRs) are part of the innate immune response to microbes; by recognition of distinct features, they link to induction of pro-inflammatory signaling pathways. We immunostained TLR 3, 7, and 9 in 27 JNA specimens of patients treated at the Helsinki University Central Hospital, Helsinki, Finland, during the years 1970-2009.\nTLR 3, 7, and 9 expressions were found in stromal and endothelial cells of JNA, and their expression levels varied from negative to very strong positive. TLR 3 expression was found to have a significant correlation with the clinical stage of JNA.\nThe present results propose a putative role of TLRs in the growth process of JNA.\nUNLABELLED\nRESULTS\nCONCLUSIONS
Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign tumor affecting adolescent males. The etiology of JNA as well as the causes determining the variable growth patterns of individual tumors remains unknown. Toll-like receptors (TLRs) are part of the innate immune response to microbes; by recognition of distinct features, they link to induction of pro-inflammatory signaling pathways. We immunostained TLR 3, 7, and 9 in 27 JNA specimens of patients treated at the Helsinki University Central Hospital, Helsinki, Finland, during the years 1970-2009.\nTLR 3, 7, and 9 expressions were found in stromal and endothelial cells of JNA, and their expression levels varied from negative to very strong positive. TLR 3 expression was found to have a significant correlation with the clinical stage of JNA.\nThe present results propose a putative role of TLRs in the growth process of JNA.\nUNLABELLED\nRESULTS\nCONCLUSIONS
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