A1 Refereed original research article in a scientific journal
TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence
Authors: Haeggblom L, Näsman A, Ramqvist T, Haglund C, Hagström J, Mäkitie A, Dalianis T
Publication year: 2019
Journal: Acta Oto-Laryngologica
Journal name in source: Acta oto-laryngologica
Journal acronym: Acta Otolaryngol
Volume: 139
Issue: 2
First page : 206
Last page: 210
Number of pages: 5
ISSN: 0001-6489
eISSN: 1651-2251
DOI: https://doi.org/10.1080/00016489.2018.1552014
Abstract
cancer. TLR5 and TLR7 expression was previously shown to differ depending on HPV - status and correlate with outcome in oropharyngeal squamous cell carcinoma.\n tumor-infiltrating lymphocyte (TIL) counts, the latter being a well-documented prognostic marker.\n) were analyzed by immunohistochemistry for TLR5 and TLR7, and correlated with the above parameters.\n TIL counts (p = .023).\n TIL counts, and TLR5 expression was disclosed, but not with TLR7. Therefore, it could be useful to investigate TLR7 further as a potential independent prognostic marker.\nBACKGROUND\nAIMS/OBJECTIVES\nMATERIALS AND METHODS\nRESULTS\nCONCLUSION AND SIGNIFICANCE
cancer. TLR5 and TLR7 expression was previously shown to differ depending on HPV - status and correlate with outcome in oropharyngeal squamous cell carcinoma.\n tumor-infiltrating lymphocyte (TIL) counts, the latter being a well-documented prognostic marker.\n) were analyzed by immunohistochemistry for TLR5 and TLR7, and correlated with the above parameters.\n TIL counts (p = .023).\n TIL counts, and TLR5 expression was disclosed, but not with TLR7. Therefore, it could be useful to investigate TLR7 further as a potential independent prognostic marker.\nBACKGROUND\nAIMS/OBJECTIVES\nMATERIALS AND METHODS\nRESULTS\nCONCLUSION AND SIGNIFICANCE
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