A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Changing trends in the management of the neck in oropharyngeal squamous cell carcinoma
Tekijät: Jouhi L, Atula T, Saarilahti K, Hagström J, Haglund C, Mohamed H, Mäkitie A, Keski-Säntti H
Julkaisuvuosi: 2017
Journal: Head and Neck
Tietokannassa oleva lehden nimi: Head & neck
Lehden akronyymi: Head Neck
Vuosikerta: 39
Numero: 7
Aloitussivu: 1412
Lopetussivu: 1420
Sivujen määrä: 9
ISSN: 1043-3074
eISSN: 1097-0347
DOI: https://doi.org/10.1002/hed.24781
Tiivistelmä
Treatment for oropharyngeal squamous cell carcinoma (SCC) has changed toward a more oncologic approach. We evaluated treatment of the neck, the incidence of regional recurrences, and factors associated with regional recurrence during the treatment approach transition period in patients with regional lymph node metastasis.\nAll patients with oropharyngeal SCC diagnosed at the Helsinki University Hospital during 2000-2009 were analyzed for clinicopathological factors, treatment, p16 expression, and regional recurrence.\nAltogether, 169 patients had a complete response, and among them regional recurrence occurred in 5 patients (4.7%) treated with surgery ± radiotherapy (RT) or chemoradiotherapy (CRT) and in 2 patients (3.2%) treated with RT or CRT ± surgery. All these 7 patients had N2b disease or higher, and 5 of them had regional recurrence in the contralateral side of the neck.\nThe incidence of regional recurrence was low, and remained unchanged despite the increased use of RT or CRT ± surgery. Treatment and follow-up of the contralateral neck warrants special attention in patients with advanced neck disease (≥N2b).\nBACKGROUND\nMETHODS\nRESULTS\nCONCLUSION
Treatment for oropharyngeal squamous cell carcinoma (SCC) has changed toward a more oncologic approach. We evaluated treatment of the neck, the incidence of regional recurrences, and factors associated with regional recurrence during the treatment approach transition period in patients with regional lymph node metastasis.\nAll patients with oropharyngeal SCC diagnosed at the Helsinki University Hospital during 2000-2009 were analyzed for clinicopathological factors, treatment, p16 expression, and regional recurrence.\nAltogether, 169 patients had a complete response, and among them regional recurrence occurred in 5 patients (4.7%) treated with surgery ± radiotherapy (RT) or chemoradiotherapy (CRT) and in 2 patients (3.2%) treated with RT or CRT ± surgery. All these 7 patients had N2b disease or higher, and 5 of them had regional recurrence in the contralateral side of the neck.\nThe incidence of regional recurrence was low, and remained unchanged despite the increased use of RT or CRT ± surgery. Treatment and follow-up of the contralateral neck warrants special attention in patients with advanced neck disease (≥N2b).\nBACKGROUND\nMETHODS\nRESULTS\nCONCLUSION
Turun yliopiston Tutkimustietojärjestelmän portaali