A3 Book chapter

Radiolabeling of Theranostic Nanosystems




List of Authors: Das Sudeep, Imlimthan Surachet, Airaksinen Anu J., Sarparanta Mirkka

Publisher: Springer

Publication year: 2021

Book title *: Bio-Nanomedicine for Cancer Therapy

Journal name in source: Advances in Experimental Medicine and Biology

Title of series: Advances in Experimental Medicine and Biology

Volume number: 1295

Number of pages: 28

ISBN: 978-3-030-58173-2

eISBN: 978-3-030-58176-3

ISSN: 0065-2598

DOI: http://dx.doi.org/10.1007/978-3-030-58174-9_3


Abstract

In the recent years, progress in nanotechnology has significantly contributed to the development of novel pharmaceutical formulations to overcome the drawbacks of conventional treatments and improve the therapeutic outcome in many diseases, especially cancer. Nanoparticle vectors have demonstrated the potential to concomitantly deliver diagnostic and therapeutic payloads to diseased tissue. Due to their special physical and chemical properties, the characteristics and function of nanoparticles are tunable based on biological molecular targets and specific desired features (e.g., surface chemistry and diagnostic radioisotope labeling). Within the past decade, several theranostic nanoparticles have been developed as a multifunctional nanosystems which combine the diagnostic and therapeutic functionalities into a single drug delivery platform. Theranostic nanosystems can provide useful information on a real-time systemic distribution of the developed nanosystem and simultaneously transport the therapeutic payload. In general, the diagnostic functionality of theranostic nanoparticles can be achieved through labeling gamma-emitted radioactive isotopes on the surface of nanoparticles which facilitates noninvasive detection using nuclear molecular imaging techniques, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), meanwhile, the therapeutic effect arises from the potent drug released from the nanoparticle. Moreover, some radioisotopes can concurrently emit both gamma radiation and high-energy particles (e.g., alpha, beta, and Auger electrons), prompting the use either alone for radiotheranostics or synergistically with chemotherapy. This chapter provides an overview of the fundamentals of radiochemistry and relevant radiolabeling strategies for theranostic nanosystem development as well as the methods for the preclinical evaluation of radiolabeled nanoparticles. Furthermore, preclinical case studies of recently developed theranostic nanosystems will be highlighted.


Last updated on 2021-24-06 at 11:18