A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood

Julkaisun tekijät: Lehtovirta Miia, Matthews Laurie A, Laitinen Tomi T, Nuotio Joel, Niinikoski Harri, Rovio Suvi P, Lagström Hanna, Viikari Jorma S A, Rönnemaa Tapani, Jula Antti, Ala-Korpela Mika, Raitakari Olli T, Pahkala Katja

Kustantaja: MDPI

Julkaisuvuosi: 2021

Journal: Nutrients

Tietokannassa oleva lehden nimi: NUTRIENTS

Lehden akronyymi: NUTRIENTS

Volyymi: 13

Julkaisunumero: 2

Sivujen määrä: 13

DOI: http://dx.doi.org/10.3390/nu13020533

The Special Turku Coronary Risk Factor Intervention Project (STRIP) is a prospective infancy-onset randomized dietary intervention trial targeting dietary fat quality and cholesterol intake, and favoring consumption of vegetables, fruit, and whole-grains. Diet (food records) and circulating metabolites were studied at six time points between the ages of 9-19 years (n = 549-338). Dietary targets for this study were defined as (1) the ratio of saturated fat (SAFA) to monounsaturated and polyunsaturated fatty acids (MUFA + PUFA) < 1:2, (2) intake of SAFA < 10% of total energy intake, (3) fiber intake >= 80th age-specific percentile, and (4) sucrose intake <= 20th age-specific percentile. Metabolic biomarkers were quantified by high-throughput nuclear magnetic resonance metabolomics. Better adherence to the dietary targets, regardless of study group allocation, was assoiated with higher serum proportion of PUFAs, lower serum proportion of SAFAs, and a higher degree of unsaturation of fatty acids. Achieving >= 1 dietary target resulted in higher low-density lipoprotein (LDL) particle size, lower circulating LDL subclass lipid concentrations, and lower circulating lipid concentrations in medium and small high-density lipoprotein subclasses compared to meeting 0 targets. Attaining more dietary targets (>= 2) was associated with a tendency to lower lipid concentrations of intermediate-density lipoprotein and very low-density lipoprotein subclasses. Thus, adherence to dietary targets is favorably associated with multiple circulating fatty acids and lipoprotein subclass lipid concentrations, indicative of better cardio-metabolic health.

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Last updated on 2021-24-06 at 10:38