A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas
Tekijät: Omar Abdirisak Ahmed Haji, Haglund Caj, Virolainen Susanna, Häyry Valtteri, Atula Timo, Kontio Risto, Salo Tuula, Sorsa Timo, Hagström Jaana
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2015
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Tietokannassa oleva lehden nimi: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
Lehden akronyymi: OR SURG OR MED OR PA
Vuosikerta: 119
Numero: 4
Aloitussivu: 459
Lopetussivu: 467
Sivujen määrä: 9
ISSN: 2212-4403
DOI: https://doi.org/10.1016/j.oooo.2014.12.019
Tiivistelmä
Objectives. Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers.
Study Design. Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies.
Results. MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients.
Conclusions. The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.
Objectives. Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers.
Study Design. Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies.
Results. MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients.
Conclusions. The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.
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