Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction




Julkaisun tekijät: Conti David V., Darst Burcu F., Moss Lilit C., Saunders Edward J., Sheng Xin, Chou Alisha, Schumacher Fredrick R., Al Olama Ali Amin, Benlloch Sara, Dadaev Tokhir, Brook Mark N., Sahimi Ali, Hoffmann Thomas J., Takahashi Atushi, Matsuda Koichi, Momozawa Yukihide, Fujita Masashi, Muir Kenneth, Lophatananon Artitaya, Wan Peggy, Le Marchand Loic, Wilkens Lynne R., Stevens Victoria L., Gapstur Susan M., Carter Brian D., Schleutker Johanna, Tammela Teuvo L. J., Sipeky Csilla, Auvinen Anssi, Giles Graham G., Southey Melissa C., MacInnis Robert J., Cybulski Cezary, Wokołorczyk Dominika, Lubiński Jan, Neal David E., Donovan Jenny L., Hamdy Freddie C., Martin Richard M., Nordestgaard Børge G., Nielsen Sune F., Weischer Maren, Bojesen Stig E., Røder Martin Andreas, Iversen Peter, Batra Jyotsna, Chambers Suzanne, Moya Leire, Horvath Lisa, Clements Judith A., Tilley Wayne, Risbridger Gail P., Gronberg Henrik, Aly Markus, Szulkin Robert, Eklund Martin, Nordström Tobias, Pashayan Nora, Dunning Alison M., Ghoussaini Maya, Travis Ruth C., Key Tim J., Riboli Elio, Park Jong Y., Sellers Thomas A., Lin Hui-Yi, Albanes Demetrius, Weinstein Stephanie J., Mucci Lorelei A., Giovannucci Edward, Lindstrom Sara, Kraft Peter, Hunter David J., Penney Kathryn L., Turman Constance, Tangen Catherine M., Goodman Phyllis J., Ian M. Thompson Ian M. Jr., Hamilton Robert J., Fleshner Neil E., Finelli Antonio, Parent Marie-Élise, Stanford Janet L., Ostrander Elaine A., Geybels Milan S., Koutros Stella, Freeman Laura E. Beane, Stampfer Meir, Wolk Alicja, Håkansson Niclas, Andriole Gerald L., Hoover Robert N., Machiela Mitchell J., Sørensen Karina Dalsgaard, Borre Michael, Blot William J., Zheng Wei, Yeboah Edward D., Mensah James E., Lu Yong-Jie, Zhang Hong-Wei, Feng Ninghan, Mao Xueying, Wu Yudong, Zhao Shan-Chao, Sun Zan, Thibodeau Stephen N., McDonnell Shannon K., Schaid Daniel J., West Catharine M. L., Burnet Neil, Barnett Gill, Maier Christiane, Schnoeller Thomas, Luedeke Manuel, Kibel Adam S., Drake Bettina F., Cussenot Olivier, Cancel-Tassin Géraldine, Menegaux Florence, Truong Thérèse, Koudou Yves Akoli, John Esther M., Grindedal Eli Marie, Maehle Lovise, Khaw Kay-Tee, Ingles Sue A., Stern Mariana C., Vega Ana, Gómez-Caamaño Antonio, Fachal Laura, Rosenstein Barry S., Kerns Sarah L., Ostrer Harry, Teixeira Manuel R., Paulo Paula, Brandão Andreia, Watya Stephen, Lubwama Alexander, Bensen Jeannette T., Fontham Elizabeth T. H., Mohler James, Taylor Jack A., Kogevinas Manolis, Llorca Javier, Castaño-Vinyals Gemma, Cannon-Albright Lisa, Teerlink Craig C., Huff Chad D., Strom Sara S., Multigner Luc, Blanchet Pascal, Brureau Laurent, Kaneva Radka, Slavov Chavdar, Mitev Vanio, Leach Robin J., Weaver Brandi, Brenner Hermann, Cuk Katarina, Holleczek Bernd, Saum Kai-Uwe, Klein Eric A., Hsing Ann W., Kittles Rick A., Murphy Adam B., Logothetis Christopher J., Kim Jeri, Neuhausen Susan L., Steele Linda, Ding Yuan Chun, Isaacs William B., Nemesure Barbara, Hennis Anselm J. M., Carpten John, Pandha Hardev, Michael Agnieszka, De Ruyck Kim, De Meerleer Gert, Ost Piet, Xu Jianfeng, Razack Azad, Lim Jasmine, Teo Soo-Hwang, Newcomb Lisa F., Lin Daniel W., Fowke Jay H., Neslund-Dudas Christine, Rybicki Benjamin A., Gamulin Marija, Lessel Davor, Kulis Tomislav, Usmani Nawaid, Singhal Sandeep, Parliament Matthew, Claessens Frank, Joniau Steven, Van den Broeck Thomas, Gago-Dominguez Manuela, Castelao Jose Esteban, Martinez Maria Elena, Larkin Samantha, Townsend Paul A., Aukim-Hastie Claire, Bush William S., Aldrich Melinda C., Crawford Dana C., Srivastava Shiv, Cullen Jennifer C., Petrovics Gyorgy, Casey Graham, Roobol Monique J., Jenster Guido, van Schaik Ron H. N., Hu Jennifer J., Sanderson Maureen, Varma Rohit, McKean-Cowdin Roberta, Torres Mina, Mancuso Nicholas, Berndt Sonja I., Van Den Eeden Stephen K., Easton Douglas F., Chanock Stephen J., Cook Michael B., Wiklund Fredrik, Nakagawa Hidewaki, Witte John S., Eeles Rosalind A., Kote-Jarai Zsofia, Haiman Christopher A.

Kustantaja: NATURE RESEARCH

Julkaisuvuosi: 2021

Journal: Nature Genetics

Tietokannassa oleva lehden nimi: NATURE GENETICS

Lehden akronyymi: NAT GENET

Volyymi: 53

Julkaisunumero: 1

Sivujen määrä: 30

ISSN: 1061-4036

eISSN: 1546-1718

DOI: http://dx.doi.org/10.1038/s41588-020-00748-0

Rinnakkaistallenteen osoite: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148035/


Tiivistelmä
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.


Last updated on 2022-03-10 at 16:10