A1 Journal article – refereed

ZnO Q-Dots-Induced Apoptosis Was Coupled with the Induction of PPAR gamma in Acute Promyelocytic Leukemia Cells; Proposing a Novel Application of Nanoparticles in Combination with Pioglitazone

List of Authors: Esmaeili Shadi, Pourbagheri-Sigaroodi Atieh, Yousefi Amir-Mohammed, Fakhroueian Zahra, Momeny Majid, Bashash Davood


Publication year: 2021

Journal: Journal of Cluster Science

Journal name in source: JOURNAL OF CLUSTER SCIENCE

Journal acronym: J CLUST SCI

Number of pages: 13

ISSN: 1040-7278

eISSN: 1572-8862

DOI: http://dx.doi.org/10.1007/s10876-021-01992-y

By the creation of nanoscale-materials, nanotechnology has emerged as one of the focal points of modern medical investigations and nanotechnology-based cancer treatment approaches found their ways into therapeutic strategies. Herein, we evaluated anticancer property and molecular mechanisms of zinc oxide quantum dot nanoparticles (ZnO QD NPs) in the form of nanofluid (NF) in acute promyelocytic leukemia (APL)-derived NB4 cells. ZnO nanofluid (ZnO NF) robustly decreased proliferation of NB4 cells through p21-mediated G1 cell cycle arrest and induced apoptosis probably via ROS-dependent upregulation of FoxO3a and SIRT1. Moreover, our study indicated for the first time that the anti-leukemic effect of ZnO NF was coupled with the up-regulation of peroxisome proliferator-activated receptors gamma (PPAR gamma) in NB4 cells. Activation of PPAR gamma using pioglitazone, not only up-regulated the effect the ZnO NF on the expression of anti-apoptotic target genes but also could significantly elevate the expression of pro-apoptotic molecules in NB4 cells, as compared to either agent alone. In conclusion, this study suggested promising anti-leukemic activity of ZnO NF against NB4 cells and proposed a novel mechanism of action through which ZnO NF may induce significant cytotoxicity in APL, either as a single or in combination with PPAR gamma agonist.

Last updated on 2021-24-06 at 10:21