A1 Refereed original research article in a scientific journal
Matrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinoma
Authors: Mäkinen Laura K, Häyry Valtteri, Hagström Jaana, Sorsa Timo, Passador-Santos Fabricio, Keski-Säntti Harri, Haukka Jari, Mäkitie Antti A, Haglund Caj, Atula Timo
Publisher: WILEY
Publication year: 2014
Journal: Head and Neck
Journal name in source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Journal acronym: HEAD NECK-J SCI SPEC
Volume: 36
Issue: 12
First page : 1783
Last page: 1788
Number of pages: 6
ISSN: 1043-3074
DOI: https://doi.org/10.1002/hed.23539
Abstract
BackgroundPredicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 and MMP-25 in oral tongue SCC.
MethodsWe used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP-7 and MMP-25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data.
ResultsImmunohistochemistry revealed MMP-7 and MMP-25 expression in 90% (n = 63 of 70) and 90% (n = 64 of 71) of the tumors, respectively. MMP-7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP-7 expression was predictive for poor outcome (p = .021). Immunostaining of MMP-25 did not correlate with any clinical parameters.
ConclusionWe conclude that MMP-7, but not MMP-25, expression may have prognostic significance in early-stage oral tongue SCC. (c) 2014 Wiley Periodicals, Inc. Head Neck 36: 1783-1788, 2014
BackgroundPredicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 and MMP-25 in oral tongue SCC.
MethodsWe used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP-7 and MMP-25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data.
ResultsImmunohistochemistry revealed MMP-7 and MMP-25 expression in 90% (n = 63 of 70) and 90% (n = 64 of 71) of the tumors, respectively. MMP-7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP-7 expression was predictive for poor outcome (p = .021). Immunostaining of MMP-25 did not correlate with any clinical parameters.
ConclusionWe conclude that MMP-7, but not MMP-25, expression may have prognostic significance in early-stage oral tongue SCC. (c) 2014 Wiley Periodicals, Inc. Head Neck 36: 1783-1788, 2014
UTU Research Portal