Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease




Julkaisun tekijät: Kalaoja Marita, Corbin Laura J, Tan Vanessa Y, Ahola-Olli Ari V, Havulinna Aki S, Santalahti Kristiina, Pitkänen Niina, Lehtimäki Terho, Lyytikäinen Leo-Pekka, Raitoharju Emma, Seppälä Ilkka, Kähönen Mika, Ripatti Samuli, Palotie Aarno, Perola Markus, Viikari Jorma S, Jalkanen Sirpa, Maksimow Mikael, Salomaa Veikko, Salmi Marko, Raitakari Olli T, Kettunen Johannes, Timpson Nicholas J

Kustantaja: WILEY

Julkaisuvuosi: 2021

Journal: Obesity

Tietokannassa oleva lehden nimi: OBESITY

Lehden akronyymi: OBESITY

Volyymi: 29

Julkaisunumero: 2

Sivujen määrä: 10

ISSN: 1930-7381

eISSN: 1930-739X

DOI: http://dx.doi.org/10.1002/oby.23060

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53043679


Tiivistelmä

Objective

This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease.

Methods

BMI and circulating levels of up to 41 cytokines were measured in individuals from three Finnish cohort studies (n = 8,293). Mendelian randomization (MR) was used to assess the impact of BMI on circulating cytokines and the impact of BMI-driven cytokines on risk of obesity-related diseases.

Results

Observationally, BMI was associated with 19 cytokines. For every SD increase in BMI, causal effect estimates were strongest for hepatocyte growth factor, monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and were as ratios of geometric means 1.13 (95% CI: 1.08-1.19), 1.08 (95% CI: 1.04-1.14), and 1.13 (95% CI: 1.04-1.21), respectively. TRAIL was associated with a small increase in the odds of coronary artery disease (odds ratio: 1.03; 95% CI: 1.00-1.06). There was inconsistent evidence for a protective role of MCP-1 against inflammatory bowel diseases.

Conclusions

Observational and MR estimates of the effect of BMI on cytokine levels were generally concordant. There was little evidence for an effect of raised levels of BMI-driven cytokines on disease. These findings illustrate the challenges of MR when applied in the context of molecular mediation.


Ladattava julkaisu

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Last updated on 2022-03-10 at 14:43