A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Increased Risk of Parkinson's Disease in Patients With Schizophrenia Spectrum Disorders
Tekijät: Kuusimäki Tomi, Al-Abdulrasul Haidar, Kurki Samu, Hietala Jarmo, Hartikainen Sirpa, Koponen Marjaana, Tolppanen Anna-Maija, Kaasinen Valtteri
Kustantaja: WILEY
Julkaisuvuosi: 2021
Journal: Movement Disorders
Tietokannassa oleva lehden nimi: MOVEMENT DISORDERS
Lehden akronyymi: MOVEMENT DISORD
Vuosikerta: 36
Numero: 6
Aloitussivu: 1353
Lopetussivu: 1361
Sivujen määrä: 10
ISSN: 0885-3185
eISSN: 1531-8257
DOI: https://doi.org/10.1002/mds.28484
Verkko-osoite: https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28484
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53043300
Background PD comorbid with schizophrenia has been considered rare because these diseases associate with opposite alterations in the brain dopamine system. The objective of this study was to investigate the risk of PD after a diagnosis of a schizophrenia spectrum disorder.Methods Regionally, this was a retrospective record-based case-control study. The cohort included 3045 PD patients treated 2004-2019 in southwestern Finland. Nationally this was a nested case-control study using registers to examine Finnish patients who received a clinically confirmed PD diagnosis 1996-2015 (n = 22,189). PD patients with previously diagnosed schizophrenia spectrum disorder (separate analysis for schizophrenia) were included. Comparable non-PD control groups were derived from both data sets. All PD diagnoses were based on individual clinical examinations by certified neurologists.Results In PD patients, the prevalence of earlier schizophrenia spectrum disorder was 0.76% in regional data and 1.50% in nationwide data. In age-matched controls, the prevalence in the regional and national data was 0.16% and 1.31%, respectively. The odds ratio for PD after schizophrenia spectrum disorder diagnosis was 4.63 (95% CI, 1.76-12.19; P < 0.01) in the regional data and 1.17 (95% CI, 1.04-1.31; P < 0.01) in the national data.Conclusions Schizophrenia spectrum disorder increases the risk of PD later in life. This association was observed in both individual patient data and nationwide register data. Therefore, despite the opposite dopaminergic disease mechanisms, schizophrenia spectrum disorder increases rather than decreases the risk of PD. The increased PD risk could be related to risk-altering effects of dopamine receptor antagonists or to the increased vulnerability of the dopamine system induced by illness phase-dependent dopamine dysregulation in schizophrenia/schizophrenia spectrum disorder. (c) 2021 International Parkinson and Movement Disorder Society
Ladattava julkaisu This is an electronic reprint of the original article. |  |
