Lack of MMP-9 expression is a marker for poor prognosis in Dukes' B colorectal cancer - UTU Research Portal

A1 Refereed original research article in a scientific journal

Lack of MMP-9 expression is a marker for poor prognosis in Dukes' B colorectal cancer

Authors: Koskensalo Selja, Hagström Jaana, Linder Nina, Lundin Mikael, Sorsa Timo, Louhimo Johanna, Haglund Caj

Publication year: 2012

Journal: BMC Clinical Pathology

Journal name in source: BMC Clinical Pathology

Article number: 24

Volume: 12

Issue: 12

ISSN: 1472-6890

DOI: https://doi.org/10.1186/1472-6890-12-24

Abstract

Background: Matrix metalloproteinases (MMPs) play a role in cancer progression by degrading extracellular matrix and basement membranes, assisting in tumour neovascularization and in supporting immune response in cancer.

Methods: We studied the prognostic value of immunohistochemical expression of MMP-2, MMP-8, and MMP-9 in a series of 619 colorectal cancer patients using tissue microarray specimens.

Results: Of the samples, 56% were positive for MMP-2, 78% for MMP-8, and 60% for MMP-9. MMP-9 associated with low WHO grade (p < 0.001). In univariate analysis of Dukes' B tumours, MMP-9 negativity associated with poor survival (p = 0.018), and MMP-9 positivity was an independent prognostic marker in multivariate analysis of these tumours (p = 0.034).

Conclusion: Negative MMP-9 expression can predict poor prognosis in Dukes' B colorectal tumours and may prove useful for identifying patients, who should be offered adjuvant treatment.