A1 Journal article – refereed

Gingival cell growth with antiresorptive treatment combined with corticosteroids or antiestrogen




List of Authors: Ekholm HM, Löyttyniemi E, Soukka T, Rautava J

Publisher: WILEY

Publication year: 2021

Journal: Clinical and Experimental Dental Research

Journal name in source: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH

Journal acronym: CLIN EXP DENT RES

Number of pages: 9

ISSN: 2057-4347

eISSN: 2057-4347

DOI: http://dx.doi.org/10.1002/cre2.382


Abstract
Objectives: Antiresorptive treatment has been shown to impair mucosal cell proliferation, migration, and viability. However, in the clinic, antiresorptives are often used in combination with other drugs. We studied the effect of antiresorptives combined with a corticosteroid or antiestrogen on oral mucosal keratinocytes and fibroblasts.Material and methods: Human gingival keratinocyte and fibroblast cell lines were exposed to bisphosphonates (BPs) and denosumab in different concentrations and durations together with an antiestrogen or corticosteroid. Changes in cell viability, proliferation and migration after exposures were measured. Data were evaluated with hierarchical linear mixed model for repeated measurements.Results: Bisphosphonate exposure suppressed keratinocyte and fibroblast cell viability, proliferation, and migration in a time-dependent manner. Combining a corticosteroid or antiestrogen with BPs further increased this negative effect. Denosumab alone had a mild positive effect on keratinocyte and fibroblast growth. When denosumab was combined with a corticosteroid or antiestrogen, cell growth was suppressed.Conclusions: Our results show that coexisting medications may increase the negative impact of BPs or denosumab on oral mucosal cells.

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Last updated on 2021-09-11 at 10:49