A1 Refereed original research article in a scientific journal
TLR-4 expression and decrease in chronic inflammation: indicators of aggressive follicular thyroid carcinoma
Authors: Hagström Jaana, Heikkila Annukka, Siironen Päivi, Louhimo Johanna, Heiskanen Ilkka, Mäenpaa Hanna, Arola Johanna, Haglund Caj
Publisher: BMJ PUBLISHING GROUP
Publication year: 2012
Journal: Journal of Clinical Pathology
Journal name in source: JOURNAL OF CLINICAL PATHOLOGY
Journal acronym: J CLIN PATHOL
Volume: 65
Issue: 4
First page : 333
Last page: 338
Number of pages: 6
ISSN: 0021-9746
DOI: https://doi.org/10.1136/jclinpath-2011-200402
Abstract
Background Well-differentiated follicular thyroid carcinoma usually has a favourable prognosis and metastases are rare. Toll-like receptors (TLRs) that take part in adaptive and innate immunity have, in many tumours, both apoptotic and antiapoptotic effects, making their role in tumourigenesis controversial. Chronic inflammation is involved in many cancers.Aims To examine the clinical relevance of TLR-2, TLR-4, and CD45 in follicular thyroid neoplasias.Methods The authors studied the immunohistochemical expression of TLR-2 and TLR-4 in 127 follicular thyroid neoplasms, both in adenomas and in carcinomas including oxyphilic tumours. Their degree of chronic inflammation was evaluated by a count of CD45-positive lymphocytes within and adjacent to the tumourous tissue.Results Both high TLR-4 expression and lack of TLR-4 expression in carcinomas were associated with metastatic and aggressive disease. In oxyphilic tumours, both in adenomas and in carcinomas, TLR-4 expression was significantly stronger. TLR-2 expression was stronger in adenomas than in carcinomas but without any correlation with clinical variables. Degree of chronic inflammation outside the primary tumour was lower for metastasized carcinomas than for non-metastasised carcinomas.Conclusions Varying expression of TLR-4 and lack of inflammation are indicators of aggressive disease among follicular thyroid cancer.
Background Well-differentiated follicular thyroid carcinoma usually has a favourable prognosis and metastases are rare. Toll-like receptors (TLRs) that take part in adaptive and innate immunity have, in many tumours, both apoptotic and antiapoptotic effects, making their role in tumourigenesis controversial. Chronic inflammation is involved in many cancers.Aims To examine the clinical relevance of TLR-2, TLR-4, and CD45 in follicular thyroid neoplasias.Methods The authors studied the immunohistochemical expression of TLR-2 and TLR-4 in 127 follicular thyroid neoplasms, both in adenomas and in carcinomas including oxyphilic tumours. Their degree of chronic inflammation was evaluated by a count of CD45-positive lymphocytes within and adjacent to the tumourous tissue.Results Both high TLR-4 expression and lack of TLR-4 expression in carcinomas were associated with metastatic and aggressive disease. In oxyphilic tumours, both in adenomas and in carcinomas, TLR-4 expression was significantly stronger. TLR-2 expression was stronger in adenomas than in carcinomas but without any correlation with clinical variables. Degree of chronic inflammation outside the primary tumour was lower for metastasized carcinomas than for non-metastasised carcinomas.Conclusions Varying expression of TLR-4 and lack of inflammation are indicators of aggressive disease among follicular thyroid cancer.
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