A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The changing surgical management of juvenile nasopharyngeal angiofibroma
Tekijät: Renkonen Suvi, Hagström Jaana, Vuola Jyrki, Niemelä Mika, Porras Matti, Kivivuori Sanna-Maria, Leivo Ilmo, Mäkitie Antti A
Kustantaja: SPRINGER
Julkaisuvuosi: 2011
Journal: European Archives of Oto-Rhino-Laryngology
Tietokannassa oleva lehden nimi: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
Lehden akronyymi: EUR ARCH OTO-RHINO-L
Vuosikerta: 268
Numero: 4
Aloitussivu: 599
Lopetussivu: 607
Sivujen määrä: 9
ISSN: 0937-4477
eISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-010-1383-z
Tiivistelmä
The management of juvenile nasopharyngeal angiofibroma (JNA) has changed during the last decades but it still continues to be a challenge for the multidisciplinary head and neck surgical team. The aim of this study was to review the used treatment approach and outcome of JNA in a single institution series of 27 patients diagnosed and treated during the years 1970-2009. All patients were male, with the median age of 17 years (range 11-33 years). Surgery was used as the primary treatment in every case. Surgical approaches varied, transpalatal approach (N = 14) being the most common approach used in this series. During the last decade various other techniques were applied, including endoscopic (N = 3) resection. Two patients were additionally treated with antiangiogenic agents and one patient with stereotactic radiotherapy. The primary recurrence rate was 37% and it seemed to correlate with vascular density of tumour and the surgical approach used. We suggest that the management of JNA should be planned by an experienced head and neck surgeon, as part of a multidisciplinary team, preferably in a tertiary referral setting, and the recent development of the available therapies should be taken into account to minimise the risk of recurrence.
The management of juvenile nasopharyngeal angiofibroma (JNA) has changed during the last decades but it still continues to be a challenge for the multidisciplinary head and neck surgical team. The aim of this study was to review the used treatment approach and outcome of JNA in a single institution series of 27 patients diagnosed and treated during the years 1970-2009. All patients were male, with the median age of 17 years (range 11-33 years). Surgery was used as the primary treatment in every case. Surgical approaches varied, transpalatal approach (N = 14) being the most common approach used in this series. During the last decade various other techniques were applied, including endoscopic (N = 3) resection. Two patients were additionally treated with antiangiogenic agents and one patient with stereotactic radiotherapy. The primary recurrence rate was 37% and it seemed to correlate with vascular density of tumour and the surgical approach used. We suggest that the management of JNA should be planned by an experienced head and neck surgeon, as part of a multidisciplinary team, preferably in a tertiary referral setting, and the recent development of the available therapies should be taken into account to minimise the risk of recurrence.
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