Tissue mechanopathology of cancer - UTU Research Portal

A2 Refereed review article in a scientific journal

Tissue mechanopathology of cancer;

Authors: Ivaska, Johanna; Sale, Sarah; Yap, Alpha S.

Publisher: Elsevier BV

Publication year: 2026

Journal: Developmental Cell

Volume: 61

Issue: 7

First page : 1392

Last page: 1406

ISSN: 1534-5807

eISSN: 1878-1551

DOI: https://doi.org/10.1016/j.devcel.2026.06.006

Publication's open availability at the time of reporting: Open Access

Publication channel's open availability : Partially Open Access publication channel

Web address : https://doi.org/10.1016/j.devcel.2026.06.006

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/526941621

Self-archived copy's licence: CC BY

Self-archived copy's version: Publisher`s PDF

Abstract

Cancers are complex cellular communities comprising tumor cells and their microenvironment. Recent advances in cancer biology have emerged from efforts to analyze tumors as tissues, in which emergent properties arise as tumor cells interact with one another, their microenvironment, and the host tissue. In this review, we consider interactions involving mechanical forces and mechanosignaling pathways that detect changes in physical inputs to regulate cellular behavior. This rapidly developing field provides perspectives for understanding cancer biology and tumor interactions with the host ecosystem.

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Funding information in the publication:
J.I. was funded by Research Council of Finland Centre of Excellence program
(grant nos. 346131 and 364182) and Academy professorship (369992). This
project was supported by an ERC grant (BorderControl; grant agreement num
ber 101142305 to J.I.) funded by the European Union. The views and opinions
expressed are however those of the author(s) only and do not necessarily
reflect those of the European Union or the European Research Council Exec
utive Agency. Neither the European Union nor the granting authority can be
held responsible for them.
S.S. and A.S.Y. were funded by the National Health and Medical Research
Council of Australia (grants 2010704 and 2036946) and the Australian
Research Council (DP220103951 and DP260103470). A.S.Y. is an Australian
Laureate Fellow of the ARC (FL230100100)