A2 Refereed review article in a scientific journal

Is p16 an adequate surrogate for human papillomavirus status determination?




AuthorsJouhi Lauri, Hagström Jaana, Atula Timo, Mäkitie Antti

PublisherLIPPINCOTT WILLIAMS & WILKINS

Publication year2017

JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery

Journal name in sourceCURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY

Journal acronymCURR OPIN OTOLARYNGO

Volume25

Issue2

First page 108

Last page112

Number of pages5

ISSN1068-9508

DOIhttps://doi.org/10.1097/MOO.0000000000000341


Abstract
Purpose of reviewIn head and neck cancer management, immunoexpression of protein p16 is widely used as a surrogate marker for human papillomavirus (HPV) positivity due to challenges of direct HPV testing. Previously p16 has been reported to have good sensitivity but only moderate specificity in HPV-status determination. The aim of this review is to evaluate the existing information on sensitivity and specificity of p16 immunohistochemistry (IHC) in HPV-status determination among the recent studies.
Recent findingsWe searched the time period from October 2014 to April 2016 and included 28 studies (a total of 31 analyses), which reported both p16 and HPV status in their series. The sensitivity of p16 in HPV determination ranged between 28.2 and 100.0%. The mean and median sensitivities were 90.5 and 95.4%, respectively. The specificity ranged between 31.1 and 100.0%. The mean and median specificities were 83.3 and 87.3%, respectively.
SummaryOur review presents current information on the feasibility of p16 IHC in HPV status determination, which is in line with previous studies. Patients with HPV-positive tumors can be identified with p16 IHC, but a risk for misclassification of HPV-negative tumors as HPV positive exists. This fact has to be taken into consideration if HPV status will influence treatment planning.



Last updated on 2024-26-11 at 21:54