A2 Refereed review article in a scientific journal
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Authors: Ulaszewska MM, Weinert CH, Trimigno A, Portmann R, Andres Lacueva C, Badertscher R, Brennan L, Brunius C, Bub A, Capozzi F, Cialiè Rosso M, Cordero CE, Daniel H, Durand S, Egert B, Feskens EJM, Ferrario PG, Garcia-Aloy M, Franceschi P, Giesbertz P, Giacomoni F, Hanhineva K, González-Domínguez R, Kopka J, Hemeryck LY, Llorach R, Kulling SE, Mattivi F, Manach C, Münger LH, Migné C, Pimentel G, Pujos-Guillot E, Ott B, Picone G, Rombouts C, Rubert J, Riccadonna S, Rist MJ, Van Meulebroek L, Vanhaecke L, Skurk T, Sri Harsha PSC, Vergères G, Vázquez-Fresno R, Wishart D
Publication year: 2019
Journal: Molecular Nutrition and Food Research
Journal name in source: Molecular nutrition & food research
Journal acronym: Mol Nutr Food Res
Volume: 63
Issue: 1
Number of pages: 38
ISSN: 1613-4125
eISSN: 1613-4133
DOI: https://doi.org/10.1002/mnfr.201800384(external)
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
