A1 Refereed original research article in a scientific journal
Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice
Authors: Rosa NN, Pekkinen J, Zavala K, Fouret G, Korkmaz A, Feillet-Coudray C, Atalay M, Hanhineva K, Mykkänen H, Poutanen K, Micard V
Publication year: 2014
Journal: Journal of Agricultural and Food Chemistry
Journal name in source: Journal of agricultural and food chemistry
Journal acronym: J Agric Food Chem
Volume: 62
Issue: 41
First page : 10101
Last page: 9
Number of pages: 9
ISSN: 0021-8561
eISSN: 1520-5118
DOI: https://doi.org/10.1021/jf503314a
Abstract
The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
UTU Research Portal