A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?
Tekijät: Bento-Silva A, Koistinen VM, Mena P, Bronze MR, Hanhineva K, Sahlstrøm S, Kitrytė V, Moco S, Aura AM
Julkaisuvuosi: 2020
Journal: European Journal of Nutrition
Tietokannassa oleva lehden nimi: European journal of nutrition
Lehden akronyymi: Eur J Nutr
Vuosikerta: 59
Numero: 4
Aloitussivu: 1275
Lopetussivu: 1293
Sivujen määrä: 19
ISSN: 1436-6207
eISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-01987-6
Tiivistelmä
Phenolic acids are important phenolic compounds widespread in foods, contributing to nutritional and organoleptic properties.\nThe bioavailability of these compounds depends on their free or conjugated presence in food matrices, which is also affected by food processing. Phenolic acids undergo metabolism by the host and residing intestinal microbiota, which causes conjugations and structural modifications of the compounds. Human responses, metabolite profiles and health responses of phenolics, show considerable individual variation, which is affected by absorption, metabolism and genetic variations of subjects.\nA better understanding of the gut-host interplay and microbiome biochemistry is becoming highly relevant in understanding the impact of diet and its constituents. It is common to study metabolism and health benefits separately, with some exceptions; however, it should be preferred that health responders and non-responders are studied in combination with explanatory metabolite profiles and gene variants. This approach could turn interindividual variation from a problem in human research to an asset for research on personalized nutrition.\nINTRODUCTION\nFACTORS AFFCETING INDIVIDUAL VARIABILITY\nOPINION
Phenolic acids are important phenolic compounds widespread in foods, contributing to nutritional and organoleptic properties.\nThe bioavailability of these compounds depends on their free or conjugated presence in food matrices, which is also affected by food processing. Phenolic acids undergo metabolism by the host and residing intestinal microbiota, which causes conjugations and structural modifications of the compounds. Human responses, metabolite profiles and health responses of phenolics, show considerable individual variation, which is affected by absorption, metabolism and genetic variations of subjects.\nA better understanding of the gut-host interplay and microbiome biochemistry is becoming highly relevant in understanding the impact of diet and its constituents. It is common to study metabolism and health benefits separately, with some exceptions; however, it should be preferred that health responders and non-responders are studied in combination with explanatory metabolite profiles and gene variants. This approach could turn interindividual variation from a problem in human research to an asset for research on personalized nutrition.\nINTRODUCTION\nFACTORS AFFCETING INDIVIDUAL VARIABILITY\nOPINION
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