Domain Errors! A Virtual Roundtable engages with the twenty-year anniversary of Domain Errors! Cyberfeminist Practices, a subRosa anthology edited by María Fernández, Faith Wilding, and Michelle M. Wright (Autonomedia 2002) that addressed racial, economic, and gendered disparities in biotechnology and early cyberfeminist theory. A close reading of the book demonstrates the importance of early cyberfeminist conversations to strategies of resistance against the capitalist takeover of life, and how many problems of the coming decades cyberfeminism anticipated. Domain Errors! editors, contributors, and subRosa members answer roundtable questions posed by Aristarkhova and Willis. María Fernández, Laleh Mehran, Michelle M. Wright, Susanna Paasonen, Amelia Jones, Nell Tenhaaf, and Tania Kupczak offer reflective, generous, and inspiring responses, exploring their evolving relationships to cyberfeminism and their own scholarly, pedagogical, activist, and creative interests.