A2 Review article in a scientific journal

Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations

List of Authors: Lamichhane Santosh, Sen Partho, Amaral Alves Marina, Ribeiro Henrique C, Raunioniemi Peppi, Hyötyläinen Tuulia, Orešič Matej

Publisher: MDPI

Publication year: 2021

Journal: Metabolites

Journal acronym: Metabolites

Volume number: 11

Issue number: 1

eISSN: 2218-1989

DOI: http://dx.doi.org/10.3390/metabo11010055


Various studies aiming to elucidate the role of the gut microbiome-metabolome co-axis in health and disease have primarily focused on water-soluble polar metabolites, whilst non-polar microbial lipids have received less attention. The concept of microbiota-dependent lipid biotransformation is over a century old. However, only recently, several studies have shown how microbial lipids alter intestinal and circulating lipid concentrations in the host, thus impacting human lipid homeostasis. There is emerging evidence that gut microbial communities play a particularly significant role in the regulation of host cholesterol and sphingolipid homeostasis. Here, we review and discuss recent research focusing on microbe-host-lipid co-metabolism. We also discuss the interplay of human gut microbiota and molecular lipids entering host systemic circulation, and its role in health and disease.

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Last updated on 2021-24-06 at 09:54