This chapter analyses health-related issues and their implications during the Council of Florence (1438–39). This event aimed to heal the schism between the Eastern and Western Churches, but its proceedings were heavily influenced by health concerns. Illness and infirmity among both Greek and Latin participants led to frequent absences and disruptions. Interpersonal dynamics and power struggles complicated matters further. Some individuals sought compassion and understanding; others fulfilled their duties despite physical and mental discomfort; suspicions of feigned illness aggravated political and religious tensions. Despite these challenges, the Council persevered in its mission, emphasising its goal of achieving unity regardless of personal hardships. Exploring the health concerns that shaped the course of the Council offers valuable insights into aspects of medieval health and their intersections with religious and political affairs.