A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies



Tekijät: Yaiw, Koon Chu; Ferrer, Isidre A.; Söderberg-Nauclér, Cecilia; Religa, Dorota

Julkaisuvuosi: 2026

Lehti: Frontiers in Aging Neuroscience

Artikkelin numero: 1757461

Vuosikerta: 17

eISSN: 1663-4365

DOI: https://doi.org/10.3389/fnagi.2025.1757461

Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla

Julkaisukanavan avoimuus : Kokonaan avoin julkaisukanava

Verkko-osoite: https://doi.org/10.3389/fnagi.2025.1757461

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/515530097

Rinnakkaistallenteen lisenssi: CC BY

Rinnakkaistallennetun julkaisun versio: Kustantajan versio


Tiivistelmä
Human cytomegalovirus (HCMV), a ubiquitous DNA betaherpesvirus, is capable of persistent infection and immunomodulation, particularly in immunocompromised and elderly hosts. Emerging evidence links HCMV to neurodegenerative diseases through its multifaceted immunomodulatory effects. This review summarizes key viral architectures and mechanisms, epidemiological trends, and experimental data supporting HCMV's role in cognitive decline. We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration.

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Julkaisussa olevat rahoitustiedot: 
The author(s) declared that financial support was received for this work and/or its publication. This work was supported by grants from: KIFonder (41700, 38188, 35508) to KCY, King Gustaf V and Queen Victoria Foundation to DR, The Lundbeck Foundation (grant R453-2024-326), the Research Council of Finland's Flagship InFLAMES (337530, 357910, and 359346), Sigrid Jusélius Foundation (8167), The Finnish Research Impact Foundation (FRIF, 687), The Päivikki and Sakari Sohlberg Foundation (14-9436-31), Cancer Foundation Finland (69-7706) and The Swedish Medical Research Council (2022-02724) to CSN.


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