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Exosomal vimentin from adipocyte progenitors accelerates wound healing




TekijätParvanian S, Yan FX, Su DD, Coelho-Rato LS, Venu AP, Yang PR, Zou XH, Jiu YM, Chen HB, Eriksson JE, Cheng F

KustantajaWILEY

Julkaisuvuosi2020

JournalCytoskeleton

Tietokannassa oleva lehden nimiCYTOSKELETON

Lehden akronyymiCYTOSKELETON

Vuosikerta77

Numero10

Aloitussivu399

Lopetussivu413

Sivujen määrä15

ISSN1949-3584

eISSN1949-3592

DOIhttps://doi.org/10.1002/cm.21634


Tiivistelmä
Adipose stem cell-derived exosomes have great potential in accelerating cutaneous wound healing by optimizing fibroblast activities. Recent studies have demonstrated that exosomes play an active role in the transport of functional cytoskeletal proteins such as vimentin. Previously we showed that vimentin serves as a coordinator of the healing process. Therefore, we hypothesized that vimentin incorporated into the exosomes may contribute to mediate fibroblast activities in wound healing. Our results revealed that exosomal vimentin from adipocyte progenitor cells acts as a promoter of fibroblast proliferation, migration, and ECM secretion. Furthermore, our in vitro and in vivo experiments provide evidence that exosomal vimentin shortens the healing time and reduces scar formation. These findings suggest the reciprocal roles of exosomes and vimentin in accelerating wound healing. Exosomes can serve as an efficient transportation system to deliver and internalize vimentin into target cells, while vimentin could have an impact on exosome transportation, internalization, and cell communication.



Last updated on 2024-26-11 at 11:33