A1 Refereed original research article in a scientific journal
Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[F-18]FMeNER-D-2: a human whole-body PET study
Authors: Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
Publisher: SPRINGER
Publication year: 2008
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Journal acronym: EUR J NUCL MED MOL I
Volume: 35
Issue: 3
First page : 630
Last page: 636
Number of pages: 7
ISSN: 1619-7070
DOI: https://doi.org/10.1007/s00259-007-0622-z
Abstract
Purpose (S,S)-[F-18]FMeNER-D-2 is a recently developed positron-emission tomography (PET) radioligand for in vivo quantification of the norepinephrine transporter system. The aim of this study was to provide dosimetry estimates for (S,S)-[F-18]FMeNER-D-2 based on human whole-body PET measurements.Methods PET scans were performed for a total of 6.4 h after the injection of 168.9 +/- 31.5 MBq of (S,S)-[F-18]FMeNER-D-2 in four healthy male subjects. Volumes of interest were drawn on the coronal images. Estimates of the absorbed dose of radiation were calculated using the OLINDA software.Results Uptake was largest in lungs, followed by liver, bladder, brain and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lung (21.6%ID at 0.3 h), liver (5.1%ID at 0.3 h), bladder (12.2%ID at 6 h) and brain (2.3%ID at 0.3 h). The largest absorbed dose was found in the urinary bladder wall (0.039 mGy/MBq). The calculated effective dose was 0.017 mSv/MBq.Conclusion Based on the distribution and dose estimates, the estimated radiation burden of (S,S)-[F-18]FMeNER-D-2 is lower than that of [F-18]FDG. The radioligand would allow multiple PET examinations in the same research subject per year.
Purpose (S,S)-[F-18]FMeNER-D-2 is a recently developed positron-emission tomography (PET) radioligand for in vivo quantification of the norepinephrine transporter system. The aim of this study was to provide dosimetry estimates for (S,S)-[F-18]FMeNER-D-2 based on human whole-body PET measurements.Methods PET scans were performed for a total of 6.4 h after the injection of 168.9 +/- 31.5 MBq of (S,S)-[F-18]FMeNER-D-2 in four healthy male subjects. Volumes of interest were drawn on the coronal images. Estimates of the absorbed dose of radiation were calculated using the OLINDA software.Results Uptake was largest in lungs, followed by liver, bladder, brain and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lung (21.6%ID at 0.3 h), liver (5.1%ID at 0.3 h), bladder (12.2%ID at 6 h) and brain (2.3%ID at 0.3 h). The largest absorbed dose was found in the urinary bladder wall (0.039 mGy/MBq). The calculated effective dose was 0.017 mSv/MBq.Conclusion Based on the distribution and dose estimates, the estimated radiation burden of (S,S)-[F-18]FMeNER-D-2 is lower than that of [F-18]FDG. The radioligand would allow multiple PET examinations in the same research subject per year.
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