Refereed journal article or data article (A1)

Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study

List of AuthorsHeiskanen Jarkko S, Hernesniemi Jussi A, Ruohonen Saku, Hutri-Kähönen Nina, Kähonen Mika, Jokinen Eero, Tossavainen Päivi, Kallio Merja, Laitinen Tomi, Lehtimäki Terho, Viikari Jorma, Juonala Markus, Nevalainen Jaakko, Raitakari Olli T


Publication year2021

JournalAnnals of Medicine

Journal name in sourceANNALS OF MEDICINE

Journal acronymANN MED

Volume number53

Issue number1

Start page160

End page168

Number of pages9





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Increased left ventricular mass (LVM) predicts cardiovascular events and mortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure (SPB) affects the left ventricular structure in adulthood.


We used longitudinal data from a 31-year follow-up to examine the associations between early-life (between ages 6-18) BMI and SPB on LVM in an adult population (N = 1864, aged 34-49). The burden of early-life BMI and SBP was defined as area under the curve.


After accounting for contemporary adult determinants of LVM, early-life BMI burden associated significantly with LVM (3.61 g/SD increase in early-life BMI; [1.94 - 5.28], p < 0.001). Overweight in early-life (age- and sex-specific BMI values corresponding to adult BMI > 25 kg/m2) associated with 4.7% (2.5-6.9%, p < 0.0001) higher LVM regardless of BMI status in adulthood. Overweight in early-life combined with obesity in adulthood (BMI > 30kg/m2) resulted in a 21% (17.3-32.9%, p < 0.0001) increase in LVM. Higher early-life BMI was associated with a risk of developing eccentric hypertrophy. The burden of early-life SPB was not associated with adult LVM or left ventricular remodeling.


High BMI in early-life confers a sustained effect on LVM and the risk for eccentric hypertrophy independently of adulthood risk factors.

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Last updated on 2022-29-09 at 14:20