A1 Refereed original research article in a scientific journal
Effects of perioperatively administered dexamethasone on surgical wound healing in patients undergoing surgery for zygomatic fracture: a prospective study
Authors: Snall J, Kormi E, Koivusalo AM, Lindqvist C, Suominen AL, Tornwall J, Thoren H
Publisher: ELSEVIER SCIENCE INC
Publication year: 2014
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Journal name in source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
Journal acronym: OR SURG OR MED OR PA
Volume: 117
Issue: 6
First page : 685
Last page: 689
Number of pages: 5
ISSN: 2212-4403
DOI: https://doi.org/10.1016/j.oooo.2014.02.033
Abstract
Objective. The aims of the study were to clarify the occurrence of disturbance in surgical wound healing (DSWH) after surgery of zygomatic complex (ZC) fractures and to determine whether perioperatively applied dexamethasone increases the risk for DSWH.Study Design. Of 64 patients who were included in a single-blind prospective trial, 33 perioperatively received a total dose of 10 mg or 30 mg of dexamethasone. The remaining 31 patients served as controls.Results. DSWH occurred in 9 patients (14.1%). Occurrence of DSWH was 24.4% in patients who received dexamethasone and 3.2% in controls. The association between DSWH and dexamethasone was significant (P=.016). Intraoral approach also was associated with DSWH significantly (P=.042). No association emerged between DSWH and age, gender, time span from accident to surgery, or duration of surgery.Conclusions. DSWH occurred significantly more frequently in patients who received perioperative dexamethasone. Because of increased risk of DSWH, perioperative dexamethasone cannot be recommended in open reduction and fixation of ZC fractures.
Objective. The aims of the study were to clarify the occurrence of disturbance in surgical wound healing (DSWH) after surgery of zygomatic complex (ZC) fractures and to determine whether perioperatively applied dexamethasone increases the risk for DSWH.Study Design. Of 64 patients who were included in a single-blind prospective trial, 33 perioperatively received a total dose of 10 mg or 30 mg of dexamethasone. The remaining 31 patients served as controls.Results. DSWH occurred in 9 patients (14.1%). Occurrence of DSWH was 24.4% in patients who received dexamethasone and 3.2% in controls. The association between DSWH and dexamethasone was significant (P=.016). Intraoral approach also was associated with DSWH significantly (P=.042). No association emerged between DSWH and age, gender, time span from accident to surgery, or duration of surgery.Conclusions. DSWH occurred significantly more frequently in patients who received perioperative dexamethasone. Because of increased risk of DSWH, perioperative dexamethasone cannot be recommended in open reduction and fixation of ZC fractures.
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