Refereed journal article or data article (A1)

‘Expedited Interhemispheric Inhibition’: A Simple Method to Collect Additional IHI Data in the Same Amount of Time

List of Authors: Corp Daniel T., He Jason, Cooke Danielle, Perellón-Alfonso Ruben, Joutsa Juho, Pascual-Leone Alvaro, Fox Michael D., Hyde Christian

Publisher: Springer

Publication year: 2021

Journal: Brain Topography

Journal name in source: Brain Topography

Volume number: 34

Number of pages: 5

eISSN: 1573-6792



Interhemispheric inhibition (IHI) is a dual-site TMS protocol measuring inhibitory interactions between the primary motor cortices (M1). IHI is performed by applying an initial conditioning stimulus followed by a test stimulus to the contralateral M1. Conventionally, the response in the contralateral hand to the conditioning TMS pulse is either not measured, or discarded. The aim of this experiment was to investigate whether MEPs evoked from these conditioning stimuli can be utilised as non-conditioned, or ‘baseline’, responses, and therefore expedite IHI data collection. We evaluated short-latency (10 ms) and long-latency (40 ms) IHI bidirectionally in 14 healthy participants. There was no difference in MEP amplitudes evoked by conventional single TMS pulses randomly inserted into IHI blocks, and those evoked by the conditioning stimulus. Nor was there any significant difference in IHI magnitude when using single pulse MEPs or conditioning stimulus MEPs as baseline responses. The utilisation of conditioning stimuli dispenses with the need to insert dedicated single TMS pulses into IHI blocks, allowing for additional IHI data to be collected in the same amount of time.

Last updated on 2022-23-02 at 09:10