A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study
Tekijät: Clasen, Joanna L.; Jonsdottir, Berglind; Vehik, Kendra; Lynch, Kristian F.; Parikh, Hemang M.; Koskenniemi, Jaakko J.; Lernmark, Åke; Agardh, Daniel; Hagopian, William A.; Rewers, Marian J.; Toppari, Jorma; Ziegler, Anette-Gabriele; Akolkar, Beena; Krischer, Jeffrey P.; Haller, Michael; Elding Larsson, Helena
Kustantaja: Oxford University Press (OUP)
Julkaisuvuosi: 2026
Lehti: American Journal of Epidemiology
Artikkelin numero: kwag016
ISSN: 0002-9262
eISSN: 1476-6256
DOI: https://doi.org/10.1093/aje/kwag016
Julkaisun avoimuus kirjaamishetkellä: Ei avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1093/aje/kwag016
We aimed to determine if thyroid autoimmunity is associated with a child’s risk for subsequent development of islet or celiac autoantibodies.
Children at high genetic risk of type 1 diabetes were followed for thyroid autoimmunity (thyroid peroxidase antibodies [TPOAb] and thyroglobulin antibodies [TGAb]), islet autoimmunity (IA), and celiac disease autoimmunity [CDA] in The Environmental Determinants of Diabetes in the Young (TEDDY) study.
Out of 5482 children tested for thyroid autoimmunity, IA, and CDA, 39% developed at least one autoantibody. At age 14 years, thyroid autoimmunity co-occurred with IA in 59 children (15 more cases than expected by chance alone, p = 0.02), and with CDA in 125 children (26 cases above expected, p = 0.01). The risk of developing IA or CDA after thyroid autoimmunity varied by which thyroid autoantibody appeared first: TPOAb-first was associated with both IA (HR 1.92, 95% CI 1.09, 3.40) and CDA (1.69, 95% CI 1.03, 2.76), whereas TGAb-first was not associated with the risk of either.
IA and CDA are frequently found in connection to thyroid autoimmunity in children and young adolescents. The relationships of thyroid autoimmunity with IA and CDA depend on which thyroid autoantibody appears first.
Julkaisussa olevat rahoitustiedot:
The TEDDY Study is funded by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, U01 DK124166, U01 DK128847, and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention (CDC), and Breakthrough T1D (formerly JDRF). This work is supported in part by the NIH/NCATS Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR002535). The content is solely the authors' responsibility and does not necessarily represent the official views of the National Institutes of Health.
