Interleukin-1 receptor-associated kinase-4gene variation may increase post-bronchiolitis asthma risk

: Matti Korppi, Johanna Teräsjärvi, Eero Lauhkonen, Sari Törmänen, Qiushui He, Kirsi Nuolivirta

Publisher: WILEY

: 2020

: Acta Paediatrica

: ACTA PAEDIATRICA

: ACTA PAEDIATR

: 7

: 0803-5253

: 1651-2227

DOI: https://doi.org/10.1111/apa.15607

Aim: Evidence based on studies of the encoding genes suggests that interleukin-1 receptor-associated kinase-4 (IRAK4) plays a role in childhood asthma and allergy. Our aim was to evaluate the associations of sixIRAK4gene polymorphisms with presence of asthma and allergic rhinitis and use of inhaled corticosteroids (ICSs) for asthma at 5-7 and 11-13 years of ages after hospitalisation for bronchiolitis at younger than 6 months of age.
Methods: IRAK4rs4251513, rs4251520, rs4251522, rs4251578, rs79154645 and rs13852554 polymorphisms were determined in 141 former bronchiolitis patients prospectively followed up until 5-7 and in 125 children until 11-13 years of age.
Results: The homozygous variantIRAK4rs4251513 genotype was associated with the presence of asthma and allergic rhinitis and use of ICSs at 5-7 and 11-13 years of ages in univariate analyses. Statistical significance remained for the presence of asthma and use of ICSs but was lost in the case of allergic rhinitis in multivariate analyses. The adjusted odds ratios were 3.48 and 4.16 for asthma and 5.22 and 14.00 for ICS use at these two ages.
Conclusion: The homozygous variantIRAK4rs4251513 genotype was constantly associated with post-bronchiolitis asthma and asthma medication in school-aged children.