A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Nuclear and cytosolic JNK signalling in neurons




TekijätCoffey ET

KustantajaNATURE PUBLISHING GROUP

Julkaisuvuosi2014

JournalNature Reviews Neuroscience

Tietokannassa oleva lehden nimiNATURE REVIEWS NEUROSCIENCE

Lehden akronyymiNAT REV NEUROSCI

Vuosikerta15

Numero5

Aloitussivu285

Lopetussivu299

Sivujen määrä15

ISSN1471-003X

eISSN1471-0048

DOIhttps://doi.org/10.1038/nrn3729


Tiivistelmä
It has been over 20 years since JUN amino-terminal kinases (JNKs) were identified as protein kinases that are strongly activated by cellular stress and that have a key role in apoptosis. Examination of Jnk-knockout mice and characterization of JNK behaviour in neuronal cells has further revealed the importance of the JNK family in the nervous system. As well as regulating neuronal death, JNKs govern brain morphogenesis and axodendritic architecture during development, and regulate important neuron-specific functions such as synaptic plasticity and memory formation. This Review examines the evidence that the spatial segregation of JNKs in neurons underlies their distinct functions and that compartment-specific targeting of JNKs may offer promising new therapeutic avenues for the treatment of diseases of the nervous system, such as stroke and neurodegenerative disorders.



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