A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Interleukin 17Fgene variations showed no association with BCG osteitis risk after newborn vaccination
Tekijät: Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Alex-Mikael Barkoff, Eero Lauhkonen, Heini Huhtala, Laura Pöyhönen, Kirsi Nuolivirta, Qiushui He
Kustantaja: WILEY
Julkaisuvuosi: 2020
Journal: Acta Paediatrica
Tietokannassa oleva lehden nimi: ACTA PAEDIATRICA
Lehden akronyymi: ACTA PAEDIATR
Vuosikerta: 110
Numero: 2
Sivujen määrä: 6
ISSN: 0803-5253
eISSN: 1651-2227
DOI: https://doi.org/10.1111/apa.15574
Tiivistelmä
Aim Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association betweenIL17Avariations and Bacillus Calmette-Guerin (BCG) osteitis. This paper evaluates the association of threeIL17Fpolymorphisms with BCG osteitis after newborn vaccination. Methods IL17Frs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database. Results There were no significant differences between former BCG osteitis patients and population-based controls in theIL17Frs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the threeIL17FSNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database. Conclusion IL17Frs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.
Aim Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association betweenIL17Avariations and Bacillus Calmette-Guerin (BCG) osteitis. This paper evaluates the association of threeIL17Fpolymorphisms with BCG osteitis after newborn vaccination. Methods IL17Frs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database. Results There were no significant differences between former BCG osteitis patients and population-based controls in theIL17Frs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the threeIL17FSNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database. Conclusion IL17Frs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.
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