Refereed journal article or data article (A1)

Interleukin 17Fgene variations showed no association with BCG osteitis risk after newborn vaccination




List of Authors: Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Alex-Mikael Barkoff, Eero Lauhkonen, Heini Huhtala, Laura Pöyhönen, Kirsi Nuolivirta, Qiushui He

Publisher: WILEY

Publication year: 2020

Journal: Acta Paediatrica

Journal name in source: ACTA PAEDIATRICA

Journal acronym: ACTA PAEDIATR

Volume number: 110

Issue number: 2

Number of pages: 6

ISSN: 0803-5253

eISSN: 1651-2227

DOI: http://dx.doi.org/10.1111/apa.15574


Abstract
Aim Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association betweenIL17Avariations and Bacillus Calmette-Guerin (BCG) osteitis. This paper evaluates the association of threeIL17Fpolymorphisms with BCG osteitis after newborn vaccination. Methods IL17Frs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database. Results There were no significant differences between former BCG osteitis patients and population-based controls in theIL17Frs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the threeIL17FSNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database. Conclusion IL17Frs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.


Last updated on 2021-24-06 at 10:39