A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Genome-wide association study identifies 48 common genetic variants associated with handedness
Tekijät: Cuellar-Partida Gabriel, Tung Joyce Y., Eriksson Nicholas, Albrecht Eva, Aliev Fazil, Andreassen Ole A., Barroso Inês, Beckmann Jacques S., Boks Marco P., Boomsma Dorret I., Boyd Heather A., Breteler Monique M. B., Campbell Harry, Chasman Daniel I., Cherkas Lynn F., Davies Gail, de Geus Eco J. C., Deary Ian J., Deloukas Panos, Dick Danielle M., Duffy David L., Eriksson Johan G., Esko Tõnu, Feenstra Bjarke, Geller Frank, Gieger Christian, Giegling Ina, Gordon Scott D., Han Jiali, Hansen Thomas F., Hartmann Annette M., Hayward Caroline, Heikkilä Kauko, Hicks Andrew A., Hirschhorn Joel N., Hottenga Jouke-Jan, Huffman Jennifer E., Hwang Liang-Dar, Ikram M. Arfan, Kaprio Jaakko, Kemp John P., Khaw Kay-Tee, Klopp Norman, Konte Bettina, Kutalik Zoltan, Lahti Jari, Li Xin,Loos Ruth J. F. , Luciano Michelle, Magnusson Sigurdur H., Mangino Massimo, Marques-Vidal Pedro, Martin Nicholas G., McArdle Wendy L., McCarthy Mark I., Medina-Gomez Carolina, Melbye Mads, Melville Scott A., Metspalu Andres, Milani Lili, Mooser Vincent, Nelis Mari, Nyholt Dale R., O’Connell Kevin S., Ophoff Roel A., Palmer Cameron, Palotie Aarno, Palviainen Teemu, Pare Guillaume, Paternoster Lavinia, Peltonen Leena, Penninx Brenda W. J. H., Polasek Ozren, Pramstaller Peter P., Prokopenko Inga, Raikkonen Katri, Ripatti Samuli, Rivadeneira Fernando, Rudan Igor, Rujescu Dan, Smit Johannes H., Smith George Davey, Smoller Jordan W., Soranzo Nicole, Spector Tim D., St Pourcain Beate, Starr John M., Stefánsson Hreinn, Steinberg Stacy, Teder-Laving Maris, Thorleifsson Gudmar, Stefánsson Kári, Timpson Nicholas J., Uitterlinden André G., van Duijn Cornelia M., van Rooij Frank J. A., Vink Jaqueline M., Vollenweider Peter, Vuoksimaa Eero, Waeber Gérard, Wareham Nicholas J., Warrington Nicole, Waterworth Dawn, Werge Thomas, Wichmann H.-Erich, Widen Elisabeth, Willemsen Gonneke, Wright Alan F., Wright Margaret J., Xu Mousheng, Zhao Jing Hua, Kraft Peter, Hinds David A., Lindgren Cecilia M., Mägi Reedik, Neale Benjamin M., Evans David M., Medland Sarah E.
Kustantaja: NATURE RESEARCH
Julkaisuvuosi: 2021
Journal: Nature Human Behaviour
Tietokannassa oleva lehden nimi: NATURE HUMAN BEHAVIOUR
Lehden akronyymi: NAT HUM BEHAV
Vuosikerta: 5
Numero: 1
Aloitussivu: 59
Lopetussivu: 70
Sivujen määrä: 14
ISSN: 2397-3374
eISSN: 2397-3374
DOI: https://doi.org/10.1038/s41562-020-00956-y
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r(G) = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.
