A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Drug-induced skin reactions: a 2-year study
Tekijät: Farshchian M, Ansar A, Zamanian AB, Rahmatpour-Rokni G, Kimyai-Asadi A, Farshchian M
Kustantaja: DOVE MEDICAL PRESS LTD
Julkaisuvuosi: 2015
Lehti: Clinical, cosmetic and investigational dermatology
Tietokannassa oleva lehden nimi: CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
Lehden akronyymi: CLIN COSMET INVESTI
Vuosikerta: 8
Aloitussivu: 53
Lopetussivu: 56
Sivujen määrä: 4
ISSN: 1178-7015
DOI: https://doi.org/10.2147/CCID.S75849
Tiivistelmä
Background: The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity.
Methods: The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007-2009). In 84 cases, histopathologic examination of skin biopsies were also performed.
Results: Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-inflammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%).
Conclusion: Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.
Background: The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity.
Methods: The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007-2009). In 84 cases, histopathologic examination of skin biopsies were also performed.
Results: Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-inflammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%).
Conclusion: Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.
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