A1 Refereed original research article in a scientific journal
Deficits in monitoring self-produced speech in Parkinson's disease
Authors: Henry Railo, Niklas Nokelainen, Saara Savolainen, Valtteri Kaasinen
Publisher: ELSEVIER IRELAND LTD
Publication year: 2020
Journal: Clinical Neurophysiology
Journal name in source: CLINICAL NEUROPHYSIOLOGY
Journal acronym: CLIN NEUROPHYSIOL
Volume: 131
Issue: 9
First page : 2140
Last page: 2147
Number of pages: 8
ISSN: 1388-2457
eISSN: 1872-8952
DOI: https://doi.org/10.1016/j.clinph.2020.05.038(external)
Abstract
Objective: Speech deficits are common in Parkinson's disease, and behavioural findings suggest that the deficits may be due to impaired monitoring of self-produced speech. The neural mechanisms of speech deficits are not well understood. We examined a well-documented electrophysiological correlate of speech self-monitoring in patients with Parkinson's disease and control participants.Methods: We measured evoked electroencephalographic responses to self-produced and passively heard sounds (/a/ phonemes) in age-matched controls (N = 18), and Parkinson's disease patients who had minor speech impairment, but reported subjectively experiencing no speech deficits (N = 17).Results: During speaking, auditory evoked activity 100 ms after phonation (N1 wave) was less suppressed in Parkinson's disease than controls when compared to the activity evoked by passively heard phonemes. This difference between the groups was driven by increased amplitudes to self-produced phonemes, and reduced amplitudes passively heard phonemes in Parkinson's disease.Conclusions: The finding indicates that auditory evoked activity is abnormally modulated during speech in Parkinson's patients who do not subjectively notice speech impairment. This mechanism could play a role in producing speech deficits in as the disease progresses.Significance: Our study is the first to show abnormal early auditory electrophysiological correlates of monitoring speech in Parkinson's disease patients.
Objective: Speech deficits are common in Parkinson's disease, and behavioural findings suggest that the deficits may be due to impaired monitoring of self-produced speech. The neural mechanisms of speech deficits are not well understood. We examined a well-documented electrophysiological correlate of speech self-monitoring in patients with Parkinson's disease and control participants.Methods: We measured evoked electroencephalographic responses to self-produced and passively heard sounds (/a/ phonemes) in age-matched controls (N = 18), and Parkinson's disease patients who had minor speech impairment, but reported subjectively experiencing no speech deficits (N = 17).Results: During speaking, auditory evoked activity 100 ms after phonation (N1 wave) was less suppressed in Parkinson's disease than controls when compared to the activity evoked by passively heard phonemes. This difference between the groups was driven by increased amplitudes to self-produced phonemes, and reduced amplitudes passively heard phonemes in Parkinson's disease.Conclusions: The finding indicates that auditory evoked activity is abnormally modulated during speech in Parkinson's patients who do not subjectively notice speech impairment. This mechanism could play a role in producing speech deficits in as the disease progresses.Significance: Our study is the first to show abnormal early auditory electrophysiological correlates of monitoring speech in Parkinson's disease patients.
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