There is a growing awareness that severe TBI is a chronic health condition, affecting the post-injury life of the patients in many ways. Because there is little scientific evidence showing how the long-term post-injury care should be organized, the recommendations given in this chapter are based on extensive clinical experience on this patient group. The various aspects of long-term follow-up can be divided into supportive rehabilitation, medical professional follow-up (including medications), and social/psychosocial support. The support from patient organizations and fellow sufferers is often also very important, but is not discussed in this chapter.