A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder
Tekijät: Jaakkola, Elina; Ijas, Jani; Joutsa, Juho; Vahlberg, Tero; Myller, Elina; Eklund, Mikael; Nuuttila, Simo; Murtomäki, Kirsi; Mertsalmi, Tuomas; Levo, Reeta; Noponen, Tommi; Ihalainen, Toni; Scheperjans, Filip; Kaasinen, Valtteri
Kustantaja: Springer Science and Business Media LLC
Kustannuspaikka: BERLIN
Julkaisuvuosi: 2025
Journal: NPJ Parkinson's disease
Tietokannassa oleva lehden nimi: npj Parkinson's Disease
Lehden akronyymi: NPJ PARKINSONS DIS
Artikkelin numero: 243
Vuosikerta: 11
Sivujen määrä: 7
eISSN: 2373-8057
DOI: https://doi.org/10.1038/s41531-025-01116-7
Verkko-osoite: https://doi.org/10.1038/s41531-025-01116-7
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/499787307
Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD has been extensively studied, the role of extrastriatal monoaminergic alterations -particularly those involving serotonin - remains poorly understood. In this study, 155 PD patients underwent [I-123]FP-CIT SPECT imaging to assess striatal and extrastriatal tracer binding, reflecting dopaminergic and broader monoaminergic function, respectively. Probable RBD was identified using a validated single-question screening tool with high sensitivity and specificity. Patients with probable RBD (RBD + , n = 44) were compared to those without (RBD - , n = 111) using voxel-wise and region-of-interest analyses, controlling for age, sex, disease duration, motor and non-motor symptom severity, and cognitive function. No significant differences were observed in striatal dopamine transporter binding. However, RBD+ patients showed significantly higher extrastriatal binding in the prefrontal cortex (pFWE < 0.05), suggesting a potential role for altered extrastriatal monoaminergic neurotransmission, possibly involving serotonergic pathways, in PD-RBD pathophysiology. These findings should be interpreted with caution due to the non-selective binding profile of the radiotracer.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
This study was funded by the Finnish Cultural Foundation, the Finnish Parkinson Foundation, the Päivikki and Sakari Sohlberg Foundation, the Turku University Foundation, and Turku University Hospital (VTR-funds).
