A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Biological evaluation of a glucose‐based boron carrier as a potential agent for boron neutron capture therapy
Tekijät: Imlimthan, Surachet; Bahrami, Katayun; Pehkonen, Henna; Centanni, Alessia; Montaser, Ahmed B.; Vara, Arina; Matovic, Jelena; Liljenback, Heidi; Auchynnikava, Tatsiana; Huttunen, Kristiina M.; Roivainen, Anne; Airaksinen, Anu J.; Ekholm, Filip S.; Monni, Outi; Rautio, Jarkko; Sarparanta, Mirkka
Kustantaja: Wiley
Kustannuspaikka: HOBOKEN
Julkaisuvuosi: 2025
Journal: International Journal of Cancer
Tietokannassa oleva lehden nimi: International Journal of Cancer
Lehden akronyymi: INT J CANCER
Artikkelin numero: ijc.70054
Sivujen määrä: 11
ISSN: 0020-7136
eISSN: 1097-0215
DOI: https://doi.org/10.1002/ijc.70054
Verkko-osoite: https://doi.org/10.1002/ijc.70054
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/499202488
Boron neutron capture therapy (BNCT) is an innovative radiation oncology approach that targets tumors selectively, minimizing damage to healthy tissues through high-linear-energy-transfer particles released during the boron neutron capture reaction. Current boron carriers like sodium mercaptoundecahydrododecaborate (BSH) and L-p-boronophenylalanine (BPA) face limitations in specificity and solubility. Our recently developed 6-O-(o-carboranylmethyl)-d-glucopyranose (B-Glc) shows promise as an alternative, demonstrating strong interactions with glucose transporters in human head and neck squamous cell carcinoma (HNSCC) CAL 27 cells in vitro. This study aims to extend in vitro investigations to three additional patient-derived human HNSCC cell lines (UT-SCC-14, UT-SCC-28, and UT-SCC-42B) and to further evaluate in vivo pharmacokinetics in selected HNSCC tumor xenografts. The B-Glc showed superior uptake and favorable kinetic parameters compared to BPA and BSH in all tested cell lines. Initial positron emission tomography imaging using [F-18]fluoro-2-deoxy-d-glucose ([F-18]FDG) radiotracer confirmed increased glucose uptake in CAL 27 and UT-SCC-14 tumors in vivo, supported by glucose transporter 1 (GLUT1) expression observed in tumor section immunohistochemistry. Biodistribution studies of the B-Glc (75 mg/kg dose) revealed no significant impact of blood glucose levels on tumor uptake, with peak boron accumulation at 15-30 min post-injection, comparable uptake to the clinical BPA-fructose complex (400 mg/kg dose) performance at 60 min, achieving the required tumor boron concentration (>20 ppm) for effective BNCT. Overall, this study underscores an advancement in targeted BNCT, highlighting B-Glc as an effective GLUT1-targeting carrier for enhanced therapeutic outcome in HNSCC and the potential to use [F-18]FDG as a companion diagnostic for the glucoconjugate.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Syopäsäätiö; Jane ja Aatos Erkon Säätiö; Ruthoch and Nils-Erik Stenbaecks Stiftelse Foundation; Päivikki ja Sakari Sohlbergin Säätiö; Alfred KordelininSäätiö, Grant/AwardNumber: 220147; Academy of Finland,Grant/Award Numbers: 318422, 320102,341106, 343608, 346122, 350117, 35531
