A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Association of leisure time physical activity with gut microbiota composition in early adulthood
Tekijät: Boelius, Hanna-Mari; Aatsinki, Anna-Katariina; Heiskanen, Marja A.; Haapala, Eero A.; Munukka, Eveliina; Mykkänen, Juha; Kartiosuo, Noora; Lahti, Leo; Keskitalo, Anniina; Huovinen, Pentti; Niinikoski, Harri; Viikari, Jorma; Rönnemaa, Tapani; Lagström, Hanna; Jula, Antti; Rovio, Suvi P.; Raitakari, Olli T.; Pahkala, Katja
Kustantaja: Springer Science and Business Media LLC
Kustannuspaikka: BERLIN
Julkaisuvuosi: 2025
Journal: Scientific Reports
Tietokannassa oleva lehden nimi: Scientific Reports
Lehden akronyymi: SCI REP-UK
Artikkelin numero: 19697
Vuosikerta: 15
Numero: 1
Sivujen määrä: 12
eISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-025-02287-2
Verkko-osoite: https://doi.org/10.1038/s41598-025-02287-2
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/499006007
Physical activity is associated with compositional changes in gut microbiota. Studies applying data from general populations exhibiting varying physical activity levels are scarce. This study investigated the associations between leisure time physical activity and gut microbiota composition in a general population of young adults. Faecal samples were analyzed with 16 S rRNA sequencing and leisure time physical activity were assessed in N = 302 (176 females, 126 males) 26-year-old individuals of European descent. Leisure time physical activity was assessed using a self-administrated questionnaire and expressed as metabolic equivalent (MET) h/wk. Participants were defined as inactive (N = 83) and active (N = 219) based on estimation to meet the physical activity guidelines. Diet was assessed using food diaries. First, associations of physical activity and gut microbiota were investigated and then the models were further adjusted for diet (N = 280). While gut microbiota diversity was similar, community composition differed between the active and inactive participants. The association diluted after adjustment for diet. Moreover, 16 genera, e.g., Lactobacillus, Veillonella, and Prevotella were more abundant in the active compared with the inactive participants. After adjustment for diet, these associations, except Barnesiella, were no longer detected, but other genera were found. In conclusion, physical activity in young adults is associated with gut microbiota community composition and an increase in the abundance of genera considered beneficial for overall health. The associations are partly confounded by diet.
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This research was funded by the Academy of Finland (grant numbers: 206374, 251360, 275595, 307996, 322112 and 26081148); the Juho Vainio Foundation; the Finnish Foundation for Cardiovascular Research; the Finnish Ministry of Education and Culture; the Finnish Cultural Foundation; the Sigrid Juselius Foundation; Special Governmental grants for Health Sciences Research; the Yrjoe Jahnsson Foundation; the Finnish Medical Foundation; the Turku University Foundation; The Olvi Foundation.
