A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Prenatally androgenized PCOS mice have ovary-independent uterine dysfunction and placental inflammation aggravated by high-fat diet
Tekijät: Luyckx, Lena; Myllykangas, Milena; Saarela, Ulla; Virtanen, Nikke; Hurskainen, Elisa; Savolainen, Audrey; Ollikainen, Nadja; Norlén, Anna-Karin; Ohlsson, Claes; Poutanen, Matti; Velde, Greetje Vande; Arffman, Riikka K.; Prunskaite-Hyyryläinen, Renata; Vriens, Joris; Piltonen, Terhi T.
Kustantaja: AMER ASSOC ADVANCEMENT SCIENCE
Kustannuspaikka: WASHINGTON
Julkaisuvuosi: 2025
Journal: Science Advances
Tietokannassa oleva lehden nimi: SCIENCE ADVANCES
Lehden akronyymi: SCI ADV
Artikkelin numero: eadu3699
Vuosikerta: 11
Numero: 19
Sivujen määrä: 15
ISSN: 2375-2548
eISSN: 2375-2548
DOI: https://doi.org/10.1126/sciadv.adu3699
Verkko-osoite: https://doi.org/10.1126/sciadv.adu3699
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/498669516
Polycystic ovary syndrome (PCOS) is a common hyperandrogenic and metabolic condition in women. The syndrome is linked to subfertility and pregnancy complications, yet the independent effects of exposure to hyperandrogenism and obesity on endometrial function remain unclear. Here, PCOS-like mice were generated using prenatal androgenization (PNA) with dihydrotestosterone, followed by a prepubertal high-fat (HF) or standard diet. In ovariectomized mice, PNA impaired uterine closure during the implantation window, disrupted decidualization, and altered extracellular matrix- and inflammation-related gene expression. The effects were aggravated by the HF diet. In naturally mated, ovary-intact mice, PNA and HF diet affected decidual and placental gene expression, suggestive of placental dysfunction and inflammation, and induced fetal growth restriction. This study underlines the role of the uterus in adverse pregnancy outcomes in PCOS and identifies possible underlying mechanisms for future studies. Prepregnancy interventions targeting metabolic health and hyperandrogenism should be the next steps to optimize PCOS pregnancy outcomes.
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This work was supported by the Horizon 2020 Marie-Curie MATER Innovative Training Network [813707 (T.T.P.)], the Oulu Scholarship Foundation Grant (L.L.), the Jusélius Foundation (T.T.P.), the Novo Nordisk Foundation [NNF21OC0070372 (T.T.P.)], the Research Council of Finland [315921, 321763, and 336449 (R.K.A. and T.T.P.)], and Fonds Wetenschappelijk Onderzoek [I006524N and G0A6719N (G.V.V. and J.V.)].
