Laparoscopic surgery may be advantageous for cystic
fibrosis (CF) patients because it leads to fewer complications than open
surgery. However, it could still lead to pulmonary and cardiovascular
complications in CF patients. We aimed to systematically review the use
of laparoscopic surgery in CF patients.

A systematic review was performed in compliance with
PRISMA guidelines. A literature search was performed using
PubMed/MEDLINE, ScienceDirect, EMBASE, and Google Scholar, with “cystic
fibrosis and laparoscopic surgery” and “cystic fibrosis and minimally
invasive surgery” used as the search terms. The Grading of
Recommendations Assessment, Development, and Evaluation (GRADE) criteria
were applied. The protocol was registered with the PROSPERO register.

Six studies met the predetermined inclusion criteria;
accordingly, two studies provided high‐quality evidence and four
provided moderate‐quality evidence. The interrater correlation was
convincing (r_s = .95, P = .02, two‐tailed).
Therefore, three quantitative studies and three qualitative studies were
assessed and evidence‐graded in accordance with the GRADE protocol.

The benefits of laparoscopic surgical interventions for
patients with CF were supported with good evidential value and
recognized as a safe and suitable surgical option.